ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2013
Spectral-domain optical coherence tomography analysis in deprivational amblyopia: a pilot study with unilateral pediatric cataract patients.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Long-term effects of early/late-onset visual deprivation on macular and retinal nerve fibers layer structure: A pilot study.PloS one · 2023Article
- Evaluation of Macular Ganglion Cell-Inner Plexiform Layer in Children with Deprivational Amblyopia Who Underwent Unilateral Cataract Surgery.Medicina (Kaunas, Lithuania) · 2022Article
- Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography.BMC ophthalmology · 2017Article
- Changes in macular parameters in different types of amblyopia: optical coherence tomography study.Clinical ophthalmology (Auckland, N.Z.) · 2017Article
- Interocular anatomical and visual functional differences in pediatric patients with unilateral cataracts.BMC ophthalmology · 2016Article
- Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia.Journal of ophthalmology · 2015Article
- A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
- CAN Optical Coherence Tomography redefine amblyopia?Romanian journal of ophthalmologyReview
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate whether macular and peripapillary retinal nerve fiber layer (RNFL) structure differs among deprivational amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using spectral-domain optical coherence tomography (SD-OCT).
methodsMacula and optic disc of 14 unilateral pseudophakic children with deprivational amblyopia, and 14 age-matched normal children (mean age, 7.45 ± 2.57 years) were scanned with Cirrus(TM) HD-OCT. Macular, RNFL, and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured, and compared between the eyes after correction for axial length-related magnification errors.
resultsThe average RNFL thickness tended to be greater in amblyopic eyes (99.64 ± 10.11 μm) than in fellow non-amblyopic eyes (97.28 ± 12.34 μm) and normal eyes (95.38 ± 9.74 μm), but did not show statistical significance (p = 0.429, p = 0.286 respectively). The nasal RNFL thickness was significantly greater in amblyopic eyes (75.84 ± 19.22 μm) than in fellow non-amblyopic eyes (63.42 ± 14.05 μm, p = 0.037) and normal eyes (62.38 ± 9.65 μm, p = 0.043). The central macular thickness in amblyopic eyes (237.05 ± 37.74 μm) showed no significant differences compared to those of fellow non-amblyopic eyes (226.67 ± 34.71 μm) and normal eyes (233.74 ± 27.11 μm) (p = 0.137, p = 0.792 respectively). The macular GCIPL thickness showed no significant difference among the amblyopic, fellow non-amblyopic, and normal eyes (average; 78.94 ± 6.35 μm vs 78.77 ± 6.43 μm vs 82.22 ± 5.00 μm respectively, p > 0.05).
conclusionsSD-OCT analysis of deprivational amblyopic eyes with unilateral pediatric cataract demonstrated significant increase in nasal RNFL thickness compared to fellow non-amblyopic eyes and age-matched normal eyes. The macular and macular GCIPL thickness did not show any significant difference. Taken together, monocular pattern deprivation in early childhood may have changed the nasal peripapillary RNFL structure.
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