ArticleJournal of neurology2014
The effect of an APOE polymorphism on cognitive function depends on age.
Article in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Obstructive Sleep Apnea and Cerebral Microbleeds in Middle-Aged and Older Adults.JAMA network open · 2025Article
- The rising burden of Alzheimer's and other dementias: role of high fasting plasma glucose from 1990 to 2021.Frontiers in medicine · 2025Article
- Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study.PLoS medicine · 2021Observational
- The APOE ε4 allele in relation to pre- and postsurgical cognitive functioning of patients with primary brain tumors.European journal of neurology · 2021Article
- The Neurocognitive Study for the Aging: Longitudinal Analysis on the Contribution of Sex, Age, Education andFrontiers in genetics · 2021Article
- Observational
- ApoE type 4 allele affects cognitive function of aged population in Tianjin City, China.American journal of Alzheimer's disease and other dementias · 2015Article
- Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.Age (Dordrecht, Netherlands) · 2014Article
- A disease modification effect of APOE E4 on the association between urinary albumin excretion and cognition in Korean adults.Disease markers · 2014Article
- Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.Brain and neuroscience advancesArticle
- No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching.Brain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It remains controversial whether APOE E4 polymorphism is related to cognitive function in general population. We aimed to evaluate an association between the APOE E4 genotype and cognitive function, and whether this association may differ by age. Cognitive function was assessed using the Korean version of modified Mini-Mental State Examination (K-mMMSE) in 10,371 Koreans aged 45-74 years in Namwon City. According to the APOE E4 status, all participants were classified as non-carriers, heterozygotes, or homozygotes. Multiple linear and logistic regression models were used to evaluate the association between APOE genotypes and cognition. The frequency of APOE genotypes in the study population was 0.4, 10.1, 1.1, 72.9, 14.7 and 0.8 % for E2E2, E2E3, E2E4, E3E3, E3E4, and E4E4, respectively. Compared to the APOE E4 non-carriers, the heterozygotes and homozygotes showed 1.3 and 7.3 % lower K-mMMSE scores at 65-74 years and 0.8 and 4.6 % higher scores at 45-55 years, respectively. Educational attainment modified the effect of APOE E4 on cognitive function in the 45-54 age group (p for interaction =0.003), showing that the E4 carriers with no-formal education showed significantly higher cognitive function than those with formal education. The present study demonstrates that the effect of APOE E4 on cognitive function depends on age and education.
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