ArticleBrain structure & function2015
Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults.
Article in Brain structure & function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Network-Level Convergence of Adiposity-Related Gray Matter Alterations: A Coordinate-Based Connectome Mapping Meta-Analysis With Imaging Transcriptomics.Human brain mapping · 2026Pooled it
- Obesity is associated with reduced orbitofrontal cortex volume: A coordinate-based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- Neuroanatomical differences in obesity: meta-analytic findings and their validation in an independent dataset.International journal of obesity (2005) · 2019Pooled it
- Questionnaire and behavioral task measures of impulsivity are differentially associated with body mass index: A comprehensive meta-analysis.Psychological bulletin · 2017Pooled it
- Cognitive Implications of White Matter Alterations in Overweight Chinese Individuals: An NODDI and DTI Study.Brain and behavior · 2025Article
- The effects of a six-month exercise intervention on white matter microstructure in older adults at risk for diabetes.Cerebral circulation - cognition and behavior · 2024Article
- Extended and replicated white matter changes in obesity: Voxel-based and region of interest meta-analyses of diffusion tensor imaging studies.Frontiers in nutrition · 2023Article
- Editorial: Community series in overeating and decision making vulnerabilities.Frontiers in psychology · 2022Article
- "Sound" Decisions: The Combined Role of Ambient Noise and Cognitive Regulation on the Neurophysiology of Food Cravings.Frontiers in neuroscience · 2022Article
- Familial Obesity Risk and Current Excess Weight Influence Brain Structure in Adolescents.Obesity (Silver Spring, Md.) · 2021Article
- Structural Brain Changes Associated with Overweight and Obesity.Journal of obesity · 2021Review
- Iowa Gambling Task and Distortion in Perception of Body Image Among Adolescent Women With Eating Disorders.Frontiers in psychology · 2020Article
- Dynamic Causal Modeling of Insular, Striatal, and Prefrontal Cortex Activities During a Food-Specific Go/NoGo Task.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- The neuroanatomical basis of the Gambler's fallacy: A univariate and multivariate morphometric study.Human brain mapping · 2019Article
- Editorial: Overeating and Decision Making Vulnerabilities.Frontiers in psychology · 2019Article
- Structural and Functional Alterations in Betel-Quid Chewers: A Systematic Review of Neuroimaging Findings.Frontiers in psychiatry · 2019Article
- A Metabolic Obesity Profile Is Associated With Decreased Gray Matter Volume in Cognitively Healthy Older Adults.Frontiers in aging neuroscience · 2019Article
- Interaction Effect of Sex and Body Mass Index on Gray Matter Volume.Frontiers in human neuroscience · 2019Article
- Food-Specific Inhibitory Control Mediates the Effect of Disgust Sensitivity on Body Mass Index.Frontiers in psychology · 2019Article
- Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging.Frontiers in human neuroscience · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
Overweight and obesity are rapidly becoming a central public health challenge around the world. Previous studies have suggested that elevated Body Mass Index (BMI) might be associated with structural changes in both gray and white matter, but this association is still not well understood. The present study aimed to investigate the relationship between BMI and brain structure with a relatively large sample of young adults (N = 336) in a small age range (20 ± 1 years). Voxel-based morphometry results showed significant negative correlations between BMI and gray-matter volumes in the midcingulate cortex (MCC), left orbital frontal cortex, and left ventromedial prefrontal cortex. There was also a significant negative correlation between BMI and white matter integrity as indexed by fractional anisotropy in bilateral cingulum. Further tractography analysis showed a significant negative correlation between BMI and the number of fibers passing the MCC region. Regression analysis showed that gray matter and white matter in these regions both contributed to the variance of BMI. These results remained significant even when analysis was restricted to the subjects with normal weights. Finally, we found that decision-making ability (as assessed by the Iowa Gambling Task) mediated the association between the structure of the MCC (a region responsible for impulse control and decision making) and BMI. These results shed light on the structural neural basis of weight variations.
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