ArticleBrain structure & function2015
DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.
Article in Brain structure & function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Altered functional connectivity density and couplings in postpartum depression with and without anxiety.Social cognitive and affective neuroscience · 2022Article
- Association Between Brain Activation and Functional Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Bariatric surgery in obese patients reduced resting connectivity of brain regions involved with self-referential processing.Human brain mapping · 2018Article
- The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.Human molecular genetics · 2018Article
- Temporal Evolution of Brain Functional Connectivity Metrics: Could 7 Min of Rest be Enough?Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Brain structural and functional dissociated patterns in schizophrenia.BMC psychiatry · 2017Article
- Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.NeuroImage. Clinical · 2017Article
- High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Article
- Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia.Neuroscience bulletin · 2015Review
- Advances in neuroimaging research of schizophrenia in China.Shanghai archives of psychiatry · 2014Review
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders.
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