Evidence map›Paper›PMID 24146121›Full record

ReviewCirculation2013

Targeting interleukin-1 in heart disease.

Benjamin W Van Tassell, Stefano Toldo, Eleonora Mezzaroma, Antonio Abbate

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06286423 (Colchicine in Acutely Decompensated Heart Failure With Reduced Ejection Fraction), which is not on this map. Cited by 167 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06286423 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Colchicine in Acutely Decompensated Heart Failure With Reduced Ejection Fraction: a Pilot Study

TypeinterventionalSponsorUniversity of VirginiaRan2024 to 2028Enrolled30ConditionsHeart Failure, Decompensated Heart Failure, Heart Failure With Reduced Ejection FractionArmsColchicine 0.6 mg, Control/Placebo group
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.

  1. Pooled it
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  17. Mendelian randomization of autoimmune hepatitis and cardiovascular diseases.American heart journal plus : cardiology research and practice · 2025
    Article
  18. Review
  19. Review
  20. Observational

107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Benjamin W Van TassellVCU Pauley Heart Center (B.W.V.T., S.T., E.M., A.A.), Victoria Johnson Research Laboratory (B.W.V.T., S.T., E.M., A.A.), and School of Pharmacy (B.W.V.T., E.M.), Virginia Commonwealth University, Richmond, VA.
Stefano Toldo
Eleonora Mezzaroma
Antonio Abbate
Virginia Commonwealth University · US

Funding

Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Center for Clinical and Translational ResearchKL2TR000057 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2014
$1.4M
NCATS NIH HHS KL2 TR000057NCATS NIH HHS KL2TR000057NCATS NIH HHS UL1 TR000058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCoronary Artery DiseaseHumansInterleukin-1Myocardial IschemiaRisk FactorsVasculitisInterleukin-1heart diseasesinflammationinterleukins

Identifiers

PMID24146121
PMCPMC3938092
OpenAlexW2151830751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.