ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015
Why menisci show higher healing rate when repaired during ACL reconstruction? Growth factors release can be the explanation.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05053646 (Biological Augmentation Of Meniscal Repair With Marrow Venting), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biological Augmentation Of Meniscal Repair With Marrow Venting: A Randomized Controlled Trial
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Surgical repair of radial meniscus tears yields favorable healing rates: a systematic review.Journal of orthopaedic surgery and research · 2026Pooled it
- Do cartilage lesions affect the clinical outcome of anterior cruciate ligament reconstruction? A systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Pooled it
- APKASS 2024 consensus statement on anterior cruciate ligament reconstruction, Part I: Management of paediatric anterior cruciate ligament injury.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2026Article
- Current concepts in meniscal suturing techniques: indications, advantages, and limitations.EFORT open reviews · 2026Review
- Slope-reducing tibial osteotomy yields better posterior horn healing performance of longitudinal and bucket-handle tears of medial meniscus in patients undergoing ACL reconstruction: a minimum 2-year follow-up study with second-look arthroscopy.Journal of orthopaedic surgery and research · 2026Article
- Synovial Fluid Biomarkers Associated With Anterior Cruciate Ligament Injury and Reconstruction: A Systematic Review.Orthopaedic journal of sports medicine · 2026Review
- Good mid-term outcomes and over 80% survivorship rate after all-inside repair of bucket-handle and full-thickness radial tears.Journal of experimental orthopaedics · 2026Article
- Current practice of biologic augmentation techniques to enhance the healing of meniscal repairs: A collaborative survey within the Meniscus International Network (MenIN) Study Group.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- A clinical practice review: augmentation of meniscoligamentous structures for primary prevention of knee joint deterioration.Annals of joint · 2026Review
- Low Failure Rates and Favorable Outcomes of Meniscal Repair With Concomitant Anterior Cruciate Ligament Primary Repair at Minimum 2-Year Follow-up.Orthopaedic journal of sports medicine · 2026Article
- Article
- Strong living scaffolds for load-bearing musculoskeletal tissue regeneration.Materials today. Bio · 2025Review
- Current Rehabilitation Principles Following Meniscus Repairs.Current reviews in musculoskeletal medicine · 2025Review
- Long-Term Results for Meniscus Repair.Current reviews in musculoskeletal medicine · 2025Review
- Single-stage ACL reconstruction and displaced bucket handle Meniscus repair is associated with lower Meniscus repair failure rates compared to two-stage surgery.Journal of experimental orthopaedics · 2025Article
- Comparison of Subsequent Surgery After Repair in Bucket-Handle Meniscal Tears and Meniscectomy Analysis of a Large, Contained Cohort Study.Orthopaedic journal of sports medicine · 2024Article
- Biologic Augmentation of Isolated Meniscal Repair.Current reviews in musculoskeletal medicine · 2024Review
- Acute Bilateral Posterior Meniscal Root Tears in the Setting of a Noncontact Anterior Cruciate Ligament Rupture.Case reports in orthopedics · 2024Article
- Surgical Management of Traumatic Meniscus Injuries.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Review
- Inferior Healing Rate in Isolated Meniscal Repair than that in Meniscal Repair with Concomitant ACL Reconstruction Evaluated with MRI.Malaysian orthopaedic journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHealing rate of meniscus repair is higher when the suture is associated with anterior cruciate ligament reconstruction. A possible explanation can be a different pattern of release of growth factors between anterior cruciate ligament reconstruction and isolated meniscus surgery. Hypothesis of this study is that the concentrations of bFGF, TGF-β and platelet-derived growth factor (PDGF) in joint fluid, immediately after single-bundle anterior cruciate ligament reconstruction and arthroscopic partial meniscectomy, can be different.
methodsTwenty consecutive patients underwent partial medial meniscectomy and twenty consecutive patients underwent single-bundle anterior cruciate ligament reconstruction with hamstring grafts were enrolled in the study. Thirty minutes after the end of the surgical procedure, a sample of joint fluid, as well of venous blood, was collected from all the patients. Concentrations of growth factors were determined by enzyme-linked immunosorbent assay.
resultsThe peripheral blood concentration of TGF-β, bFGF and PDGF was comparable between partial meniscectomy and anterior cruciate ligament reconstruction groups. No differences between the two surgical techniques were also found in term of TGF-β and bFGF joint fluid concentration, whereas joint PDGF concentration of anterior cruciate ligament reconstruction patients was significantly higher than the one found in partial meniscectomy patients.
conclusionsA significant growth factors release was detected in the knee joint during arthroscopic surgery. PDGF concentration was significantly higher in anterior cruciate ligament reconstructed knee than in the meniscectomy group. PDGF can play an important role enhancing the healing response of meniscus suture and can be one of the biological reasons of the higher meniscal healing rate in anterior cruciate ligament reconstructed knee.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.