ArticleAntimicrobial agents and chemotherapy2014
Curcumin targets cell wall integrity via calcineurin-mediated signaling in Candida albicans.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 109 citations in OpenAlex.
- Anti-Candida activity of simplified analogs of curcumin.Archives of microbiology · 2026Article
- Calcium transport systems as virulence determinants: Mechanistic insights into fungal pathogenicity and antifungal resistance.Virulence · 2025Review
- Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review.Frontiers in immunology · 2025Review
- Sodium lignosulfonate inhibits multiple virulent proteins of human fungal pathogen Candida albicans.Archives of microbiology · 2024Article
- Repurposing Plant-Based Histone Acetyltransferase Inhibitors: A Review of Novel Therapeutic Strategies Against Drug-Resistant Fungal Biofilms.Current microbiology · 2024Review
- Photodynamic impact of curcumin enhanced silver functionalized graphene nanocomposites on Candida virulence.Discover nano · 2024Article
- Mechanism of action and synergistic effect of Eugenia uniflora extract in Candida spp.PloS one · 2024Article
- Antifungal activity of green-synthesized curcumin-coated silver nanoparticles alone and in combination with fluconazole and itraconazole againstCurrent medical mycology · 2023Article
- Sodium lignosulfonate causes cell membrane perturbation in the human fungal pathogen Candida albicans.World journal of microbiology & biotechnology · 2023Article
- Protoscolicidal effects of curcumin nanoemulsion against protoscoleces of Echinococcus granulosus.BMC complementary medicine and therapies · 2023Article
- Curcumin nanoparticles: the topical antimycotic suspension treating oral candidiasis.Odontology · 2023Article
- Bioactive Effects of Curcumin in Human Immunodeficiency Virus Infection Along with the Most Effective Isolation Techniques and Type of Nanoformulations.International journal of nanomedicine · 2022Review
- Curcumin affects function of Hsp90 and drug efflux pump ofFrontiers in cellular and infection microbiology · 2022Article
- Crosstalk between the calcineurin and cell wall integrity pathways prevents chitin overexpression in Candida albicans.Journal of cell science · 2021Article
- In vitro and in silico analysis reveals antifungal activity and potential targets of curcumin on Paracoccidioides spp.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Antifungal Activity of Curcuminoids and Difluorinated Curcumin Against Clinical Isolates of Candida Species.Advances in experimental medicine and biology · 2021Article
- Antifungal Activities of Curcuminoids and Difluorinated Curcumin Against Clinical Dermatophyte Isolates.Advances in experimental medicine and biology · 2021Article
- Javanese Turmeric (Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Does Curcumin Have a Role in the Interaction between Gut Microbiota andPathogens (Basel, Switzerland) · 2020Article
- A simplified curcumin targets the membrane of Bacillus subtilis.MicrobiologyOpen · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin (CUR) shows antifungal activity against a range of pathogenic fungi, including Candida albicans. The reported mechanisms of action of CUR include reactive oxygen species (ROS) generation, defects in the ergosterol biosynthesis pathway, decrease in hyphal development, and modulation of multidrug efflux pumps. Reportedly, each of these pathways is independently linked to the cell wall machinery in C. albicans, but surprisingly, CUR has not been previously implicated in cell wall damage. In the present study, we performed transcriptional profiling to identify the yet-unidentified targets of CUR in C. albicans. We found that, among 348 CUR-affected genes, 51 were upregulated and 297 were downregulated. Interestingly, most of the cell wall integrity pathway genes were downregulated. The possibility of the cell wall playing a critical role in the mechanism of CUR required further validation; therefore, we performed specific experiments to establish if there was any link between the two. The fractional inhibitory concentration index values of 0.24 to 0.37 show that CUR interacts synergistically with cell wall-perturbing (CWP) agents (caspofungin, calcofluor white, Congo red, and SDS). Furthermore, we could observe cell wall damage and membrane permeabilization by CUR alone, as well as synergistically with CWP agents. We also found hypersusceptibility in calcineurin and mitogen-activated protein (MAP) kinase pathway mutants against CUR, which confirmed that CUR also targets cell wall biosynthesis in C. albicans. Together, these data provide strong evidence that CUR disrupts cell wall integrity in C. albicans. This new information on the mechanistic action of CUR could be employed in improving treatment strategies and in combinatorial drug therapy.
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