ArticleThe Journal of experimental medicine2013
SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons.Life science alliance · 2022Article
- Immunotherapy of glioblastoma explants induces interferon-γ responses and spatial immune cell rearrangements in tumor center, but not periphery.Science advances · 2022Article
- Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability.BMC biology · 2022Article
- Microglia in Prion Diseases: Angels or Demons?International journal of molecular sciences · 2020Review
- Genome-wide transcriptomics identifies an early preclinical signature of prion infection.PLoS pathogens · 2020Article
- Prion protein deficiency impairs hematopoietic stem cell determination and sensitizes myeloid progenitors to irradiation.Haematologica · 2020Article
- Review
- Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression.Scientific reports · 2018Article
- Prions, prionoids and protein misfolding disorders.Nature reviews. Genetics · 2018Review
- The biological function of the cellular prion protein: an update.BMC biology · 2017Review
- Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection.Journal of leukocyte biology · 2017Article
- Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling.PloS one · 2017Article
- Article
- Physiological Functions of the Cellular Prion Protein.Frontiers in molecular biosciences · 2017Review
- Cystatin F is a biomarker of prion pathogenesis in mice.PloS one · 2017Article
- Review
- Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.The Journal of experimental medicine · 2016Article
- Article
- Article
- Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory.Prion · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prnp(-/-) mice lack the prion protein PrP(C) and are resistant to prion infections, but variable phenotypes have been reported in Prnp(-/-) mice and the physiological function of PrP(C) remains poorly understood. Here we examined a cell-autonomous phenotype, inhibition of macrophage phagocytosis of apoptotic cells, previously reported in Prnp(-/-) mice. Using formal genetic, genomic, and immunological analyses, we found that the regulation of phagocytosis previously ascribed to PrP(C) is instead controlled by a linked locus encoding the signal regulatory protein α (Sirpa). These findings indicate that control of phagocytosis was previously misattributed to the prion protein and illustrate the requirement for stringent approaches to eliminate confounding effects of flanking genes in studies modeling human disease in gene-targeted mice. The plethora of seemingly unrelated functions attributed to PrP(C) suggests that additional phenotypes reported in Prnp(-/-) mice may actually relate to Sirpa or other genetic confounders.
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