ArticleScientific reports2013
Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Genome-scale metabolic model of the versatile bacteriummSystems · 2024Article
- Constraint based modeling of metabolism allows finding metabolic cancer hallmarks and identifying personalized therapeutic windows.Oncotarget · 2018Article
- Article
- Metabolic regulation is sufficient for global and robust coordination of glucose uptake, catabolism, energy production and growth in Escherichia coli.PLoS computational biology · 2017Article
- Scaling and optimal synergy: Two principles determining microbial growth in complex media.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- Validation of an FBA model for Pichia pastoris in chemostat cultures.BMC systems biology · 2014Article
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1 author.
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Abstract
The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments.
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