ArticleProceedings of the National Academy of Sciences of the United States of America2013
Pneumatic oscillator circuits for timing and control of integrated microfluidics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Living circuit boards built by printing bacterial transistors.Nature chemical biology · 2026Article
- Microfluidic pulse oscillator enabled by a shapeshifting liquid metal capacitor.Nature communications · 2026Article
- Controlling Biomedical Devices Using Pneumatic Logic.Annals of biomedical engineering · 2025Article
- Frequency-Controlled Fluidic Oscillators for Soft Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The fluidic memristor as a collective phenomenon in elastohydrodynamic networks.Nature communications · 2024Article
- High-speed fluidic processing circuits for dynamic control of haptic and robotic systems.Science advances · 2024Article
- Article
- Pneumatic computers for embedded control of microfluidics.Science advances · 2023Article
- Phase-Optimized Peristaltic Pumping by Integrated Microfluidic Logic.Micromachines · 2022Article
- Programmable soft valves for digital and analog control.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Machine learning for microfluidic design and control.Lab on a chip · 2022Review
- CMOS-Inspired Complementary Fluidic Circuits for Soft Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Fully 3D-printed soft robots with integrated fluidic circuitry.Science advances · 2021Article
- High-resolution integrated piezoresistive sensors for microfluidic monitoring.Lab on a chip · 2021Article
- Synergizing microfluidics with soft robotics: A perspective on miniaturization and future directions.Biomicrofluidics · 2021Article
- Article
- Tunable Photomechanics in Diarylethene-Driven Liquid Crystal Network Actuators.ACS applied materials & interfaces · 2020Article
- Acoustic streaming vortices enable contactless, digital control of droplets.Science advances · 2020Article
- Spontaneous oscillations and negative-conductance transitions in microfluidic networks.Science advances · 2020Article
- Light-fuelled freestyle self-oscillators.Nature communications · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frequency references are fundamental to most digital systems, providing the basis for process synchronization, timing of outputs, and waveform synthesis. Recently, there has been growing interest in digital logic systems that are constructed out of microfluidics rather than electronics, as a possible means toward fully integrated laboratory-on-a-chip systems that do not require any external control apparatus. However, the full realization of this goal has not been possible due to the lack of on-chip frequency references, thus requiring timing signals to be provided from off-chip. Although microfluidic oscillators have been demonstrated, there have been no reported efforts to characterize, model, or optimize timing accuracy, which is the fundamental metric of a clock. Here, we report pneumatic ring oscillator circuits built from microfluidic valves and channels. Further, we present a compressible-flow analysis that differs fundamentally from conventional circuit theory, and we show the utility of this physically based model for the optimization of oscillator stability. Finally, we leverage microfluidic clocks to demonstrate circuits for the generation of phase-shifted waveforms, self-driving peristaltic pumps, and frequency division. Thus, pneumatic oscillators can serve as on-chip frequency references for microfluidic digital logic circuits. On-chip clocks and pumps both constitute critical building blocks on the path toward achieving autonomous laboratory-on-a-chip devices.
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