Evidence map›Paper›PMID 24145140›Full record

ArticleCancer biology & therapy2014

mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2.

Soheila Rahgozar, Alireza Moafi, Marjan Abedi, Mansureh Entezar-E-Ghaem, Jamal Moshtaghian, Kamran Ghaedi, Abolghasem Esmaeili, Fatemeh Montazeri

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05326984 (Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05326984 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia

TypeinterventionalSponsorHospital General de MexicoRan2021 to 2023Enrolled20ConditionsAcute Lymphoblastic LeukemiaArmsMetformin
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Negative value of CD10Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
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  10. Article
  11. Review
  12. Article
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  15. Ginger extract has anti-leukemia and anti-drug resistant effects on malignant cells.Journal of cancer research and clinical oncology · 2019
    Article
  16. Review
  17. The Hedgehog signal transducerCancer management and research · 2019
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Soheila RahgozarDivision of Cell and Molecular Biology; Department of Biology; Faculty of Science; University of Isfahan; Isfahan, Iran.
Alireza MoafiDepartment of Paediatric-Oncology; Sayed ol Shohada Hospital; Isfahan University of Medical Sciences; Isfahan, Iran.
Marjan AbediDivision of Cell and Molecular Biology; Department of Biology; Faculty of Science; University of Isfahan; Isfahan, Iran.
Mansureh Entezar-E-GhaemDivision of Cell and Molecular Biology; Department of Biology; Faculty of Science; University of Isfahan; Isfahan, Iran.
Jamal MoshtaghianDivision of Cell and Molecular Biology; Department of Biology; Faculty of Science; University of Isfahan; Isfahan, Iran.
Kamran GhaediDivision of Cell and Molecular Biology; Department of Biology; Faculty of Science; University of Isfahan; Isfahan, Iran.
Abolghasem EsmaeiliDivision of Cell and Molecular Biology; Department of Biology; Faculty of Science; University of Isfahan; Isfahan, Iran.
Fatemeh MontazeriDivision of Cell and Molecular Biology; Department of Biology; Faculty of Science; University of Isfahan; Isfahan, Iran.
University of Isfahan · IRInstitute of Molecular and Cell Biology · RUIsfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug resistance (MDR) is an important cause of treatment failure in acute lymphoblastic leukemia (ALL). The ABC family of membrane transporters is proposed, albeit with controversy, to be involved in this process. The present study aims to investigate the mRNA expression profile of several genes of this family, including ABCA2, ABCA3, ABCB1/MDR1, MRP1/ABCC1, MRP3/ABCC3, ABCG2/BCRP, and the intracellular transporter MVP/LRP, in childhood ALL, and to evaluate their association with response to therapy. Some genes in the present research are being studied for the first time in Iran. Using quantitative real-time PCR, we evaluated 27 children with ALL at diagnosis and 15 children with normal bone marrow. The status of response to therapy was assessed one year after the onset of therapy through investigating the IgH/TCRγ gene rearrangements. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. Statistical analysis revealed that expression of these genes higher than the cutoff point will raise the risk of MRD by 15-, 6.25-, 12-, and 9-fold, respectively. No relationship was found between of MVP/LRP, MRP3 and ABCG2 genes expression and ALL prognoses. Considering the direct and significant relationship between the increased expression of ABCA2, ABCA3, MDR1, and MRP1 genes and positive risk of MRD in children with ALL, evaluating the expression profile of these genes on diagnosis may identify high risk individuals and help plan a more efficient treatment strategy.

Indexed as

AdolescentATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersCase-Control StudiesChildDrug Resistance, NeoplasmFemaleHumansInfantInfant, NewbornMalePrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor T-Cell Lymphoblastic Leukemia-LymphomaPrognosisRNA, MessengerABCA2 protein, humanABCA3 protein, humanATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersRNA, MessengerABC transporteracute lymphoblastic leukemiaminimal residual diseasemultidrug resistance

Identifiers

PMID24145140
PMCPMC3938522
OpenAlexW2037423947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.