ArticleBrain, behavior, and immunity2014
Cell-autonomous iodothyronine deiodinase expression mediates seasonal plasticity in immune function.
Article in Brain, behavior, and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Molecular characterization of circannual interval timing in the preoptic area and anteroventral periventricular nucleus in the Djungarian hamster (Phodopus sungorus).Journal of neuroendocrinology · 2026Article
- Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals.eLife · 2026Article
- Activity of Cardiomyocyte Type 3 Deiodinase After Myocardial Infarction Influences Cardiac Recovery in Females.Endocrinology · 2026Article
- Endocrine and molecular regulation of seasonal avian immune function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Transcriptome analyses of nine endocrine tissues identifies organism-wide transcript distribution and structure in the Siberian hamster.Scientific reports · 2022Article
- Drivers of Infectious Disease Seasonality: Potential Implications for COVID-19.Journal of biological rhythms · 2021Review
- Molecular economy of nature with two thyrotropins from different parts of the pituitary: pars tuberalis thyroid-stimulating hormone and pars distalis thyroid-stimulating hormone.Archives of medical science : AMS · 2021Article
- Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Value of Comparative Animal Research: Krogh's Principle Facilitates Scientific Discoveries.Policy insights from the behavioral and brain sciences · 2018Article
- A time for everything and everything in its time - exploring the mechanisms underlying seasonality of COPD exacerbations.International journal of chronic obstructive pulmonary disease · 2018Review
- Differential transcriptome regulation by 3,5-T2 and 3',3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia.Scientific reports · 2017Article
- A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathways.Brain, behavior, and immunity · 2017Article
- The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity.Physiological genomics · 2016Article
- Disrupted seasonal biology impacts health, food security and ecosystems.Proceedings. Biological sciences · 2015Review
- Photoperiodic time measurement and seasonal immunological plasticity.Frontiers in neuroendocrinology · 2015Review
- Neuroendocrine control of photoperiodic changes in immune function.Frontiers in neuroendocrinology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Annual rhythms in morbidity and mortality are well-documented, and host defense mechanisms undergo marked seasonal phenotypic change. Siberian hamsters (Phodopus sungorus) exhibit striking immunological plasticity following adaptation to short winter day lengths (SD), including increases in blood leukocytes and in the magnitude of T cell-mediated immune responses. Thyroid hormone (TH) signaling is rate-limited by tissue-level expression of iodothyronine deiodinase types II and III (dio2, dio3), and dio2/dio3 expression in the central nervous system gate TH-dependent transduction of photoperiod information into the neuroendocrine system. THs are also potent immunomodulators, but their role in seasonal immunobiology remains unexamined. Here we report that photoperiod-driven changes in triiodothyronine (T3) signaling mediate seasonal changes in multiple aspects of immune function. Transfer from long days (LD) to SD inhibited leukocyte dio3 expression, which increased cellular T4→T3 catabolism. T3 was preferentially localized in the lymphocyte cytoplasm, consistent with a non-nuclear role of T3 in lymphoid cell differentiation and maturation. Exposure to SD upregulated leukocyte DNA methyltransferase expression and markedly increased DNA methylation in the dio3 proximal promoter region. Lastly, to bypass low endogenous T3 biosynthesis in LD lymphocytes, LD hamsters were treated with T3, which enhanced T cell-dependent delayed-type hypersensitivity inflammatory responses and blood leukocyte concentrations in a dose-dependent manner, mimicking effects of SD on these immunophenotypes. T3 signaling represents a novel mechanism by which environmental day length cues impact the immune system: changes in day length alter lymphoid cell T3-signaling via epigenetic transcriptional control of dio3 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.