Evidence map›Paper›PMID 24145002›Full record

ArticleExperimental and molecular pathology2013

Extracellular transport of cell-size particles and tumor cells by dendritic cells in culture.

Robert I Thacker, Andrew C Retzinger, James G Cash, Michael D Dentler, Gregory S Retzinger

Open access · greenAbstract read
In one paragraph

Article in Experimental and molecular pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Robert I ThackerAmnis Corporation, EMD-Millipore, Seattle, WA 98119, United States.
Andrew C Retzinger
James G Cash
Michael D Dentler
Gregory S Retzinger
Northwestern University · USOmeros Corporation (United States) · USThe Ohio State University Wexner Medical Center · USUniversity of Cincinnati · USUniversity of Rochester Medical Center · US

Funding

Extracellular Transport of Cancer Cells by MacrophagesR21CA106257 · NCI · UNIVERSITY OF CINCINNATI · PI RETZINGER, GREGORY S · 2004 to 2005
$276k
NCI NIH HHS R21 CA106257NCI NIH HHS R21CA106257
6 · The paper itself

Abstract

Many particulate materials of sizes approximating that of a cell disseminate after being introduced into the body. While some move about within phagocytic inflammatory cells, others appear to move about outside of, but in contact with, such cells. In this report, we provide unequivocal photomicroscopic evidence that cultured, mature, human dendritic cells can transport in extracellular fashion over significant distances both polymeric beads and tumor cells. At least in the case of polymeric beads, both fibrinogen and the β2-integrin subunit, CD18, appear to play important roles in the transport process. These discoveries may yield insight into a host of disease-related phenomena, including and especially tumor cell invasion and metastasis.

Indexed as

Cell MovementCoated Materials, BiocompatibleBiological TransportBreast NeoplasmsCD18 AntigensCells, CulturedCell SizeDendritic CellsExtracellular SpaceFemaleFibrinogenHumansMonocytesCD18 AntigensCoated Materials, BiocompatibleFibrinogenCancerCell-size particlesChemotaxisDendritic cellsDirected migrationExtracellular transportInflammationMetastasisTumor cells

Identifiers

PMID24145002
PMCPMC3953141
OpenAlexW1984972442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.