ArticleInfection and immunity2014
Dormant intracellular Salmonella enterica serovar Typhimurium discriminates among Salmonella pathogenicity island 2 effectors to persist inside fibroblasts.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems inInfection and immunity · 2025Article
- Characterization of Virulence Genotypes, Antimicrobial Resistance Patterns, and Biofilm Synthesis inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Article
- Affinity of cefotiam for the alternative penicillin binding protein PBP3SAL used by Salmonella inside host eukaryotic cells.The Journal of antimicrobial chemotherapy · 2023Article
- Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. Typhimurium.PLoS pathogens · 2022Article
- Fit to dwell in many places - The growing diversity of intracellularFrontiers in cellular and infection microbiology · 2022Review
- Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling.PLoS pathogens · 2022Article
- Pathoadaptation of the passerine-associated Salmonella enterica serovar Typhimurium lineage to the avian host.PLoS pathogens · 2021Article
- A NovelFrontiers in microbiology · 2021Article
- σFrontiers in microbiology · 2021Article
- Characterization ofAnimals : an open access journal from MDPI · 2020Article
- Molecular Mechanisms ofInfection and drug resistance · 2020Review
- HilD and PhoP independently regulate the expression of grhD1, a novel gene required for Salmonella Typhimurium invasion of host cells.Scientific reports · 2018Article
- Single-cell analyses reveal an attenuated NF-κB response in the Salmonella-infected fibroblast.Virulence · 2017Article
- Review
- Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of Salmonella from the Gut Lumen and Generation of Anti-Salmonella Protective Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Intracellular Salmonella induces aggrephagy of host endomembranes in persistent infections.Autophagy · 2016Article
- Article
- Salmonellae interactions with host processes.Nature reviews. Microbiology · 2015Review
- Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica uses effector proteins delivered by type III secretion systems (TTSS) to colonize eukaryotic cells. Recent in vivo studies have shown that intracellular bacteria activate the TTSS encoded by Salmonella pathogenicity island-2 (SPI-2) to restrain growth inside phagocytes. Growth attenuation is also observed in vivo in bacteria colonizing nonphagocytic stromal cells of the intestinal lamina propria and in cultured fibroblasts. SPI-2 is required for survival of nongrowing bacteria persisting inside fibroblasts, but its induction mode and the effectors involved remain unknown. Here, we show that nongrowing dormant intracellular bacteria use the two-component system OmpR-EnvZ to induce SPI-2 expression and the PhoP-PhoQ system to regulate the time at which induction takes place, 2 h postentry. Dormant bacteria were shown to discriminate the usage of SPI-2 effectors. Among the effectors tested, SseF, SseG, and SseJ were required for survival, while others, such as SifA and SifB, were not. SifA and SifB dispensability correlated with the inability of intracellular bacteria to secrete these effectors even when overexpressed. Conversely, SseJ overproduction resulted in augmented secretion and exacerbated bacterial growth. Dormant bacteria produced other effectors, such as PipB and PipB2, that, unlike what was reported for epithelial cells, did not to traffic outside the phagosomal compartment. Therefore, permissiveness for secreting only a subset of SPI-2 effectors may be instrumental for dormancy. We propose that the S. enterica serovar Typhimurium nonproliferative intracellular lifestyle is sustained by selection of SPI-2 effectors that are produced in tightly defined amounts and delivered to phagosome-confined locations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.