Evidence map›Paper›PMID 24144471›Full record

ArticleVaccine2013

Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.

Crystal A Shanley, Elizma M Streicher, Robin M Warren, Thomas C Victor, Ian M Orme

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Crystal A ShanleyMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA. Electronic address: crystal.shanley@colostate.edu.
Elizma M Streicher
Robin M Warren
Thomas C Victor
Ian M Orme

Funding

Response Therapies for MDR-TBU01AI070456 · NIAID · COLORADO STATE UNIVERSITY · PI ORME, IAN M · 2006 to 2010
$6.4M
Virulence of MDR-TB strainsR21AI092002 · NIAID · COLORADO STATE UNIVERSITY · PI ORME, IAN M · 2012 to 2013
$408k
NIAID NIH HHS AI070456NIAID NIH HHS AI092002NIAID NIH HHS R21 AI092002NIAID NIH HHS U01 AI070456Wellcome Trust
6 · The paper itself

Abstract

The purpose of this simple study was to characterize a panel of clinical isolates of Mycobacterium tuberculosis obtained from the Western Cape region of South Africa where new clinical vaccine trials are beginning, in the low dose aerosol guinea pig infection model. Most of the strains tested grew well in the lungs and other organs of these animals, and in most cases gave rise to moderate to very severe lung damage. We further observed that the current BCG vaccine was highly protective against two randomly selected strains, giving rise to significantly prolonged survival.

Indexed as

AnimalsAntitubercular AgentsBCG VaccineDisease Models, AnimalDNA-Directed RNA PolymerasesFemaleGuinea PigsHumansLungMicrobial Sensitivity TestsMolecular TypingMycobacterium tuberculosisSouth AfricaTuberculosisAntitubercular AgentsBCG VaccineDNA-Directed RNA PolymerasesRNA polymerase beta subunitBCG vaccinationClinical strainsGuinea pigTuberculosis

Identifiers

PMID24144471
PMCPMC3886241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.