Evidence map›Paper›PMID 24144382›Full record

GuidelineThe journal of headache and pain2013

Neuromodulation of chronic headaches: position statement from the European Headache Federation.

Paolo Martelletti, Rigmor H Jensen, Andrea Antal, Roberto Arcioni, Filippo Brighina, Marina de Tommaso, Angelo Franzini, Denys Fontaine, Max Heiland, Tim P Jürgens and 7 more

2 registry-linked trialsOpen access · goldAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in The journal of headache and pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04336267 nacompletednot on this mapstarted 2015, after this paper: background citation

Anodal Transcranial Direct Current Stimulation in Chronic Migraine With and Medication Overuse Headache: a Pilot Randomized Sham-controlled Trial

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2015 to 2018Enrolled20ConditionsChronic Migraine, Medication Overuse HeadacheArmsTranscranial direct current stimulation (tDCS) group, Sham group
NCT04729270 nacompletednot on this mapstarted 2023, after this paper: background citation

Treatment of Neck Pain With Transcranial Direct Current Stimulation: A Single Blind Randomized Controlled Trial

TypeinterventionalSponsorUniversity of CadizRan2023 to 2023Enrolled30ConditionsCervical SyndromeArmsPhysiotherapy treatment with physium device., Conventional physiotherapy treatment.
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 210 citations in OpenAlex.

  1. Pooled it
  2. Digitalized transcranial electrical stimulation: A consensus statement.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Pooled it
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  6. Trial
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  11. Article
  12. Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Article
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  18. Article
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  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 6 countries.

Paolo Martelletti
Rigmor H Jensen
Andrea Antal
Roberto Arcioni
Filippo Brighina
Marina de Tommaso
Angelo Franzini
Denys Fontaine
Max Heiland
Tim P Jürgens
Massimo Leone
Delphine Magis
Koen Paemeleire
Stefano Palmisani
Walter Paulus
Arne May
European Headache Federation
Sapienza University of Rome · ITUniversität Hamburg · DEUniversity of Göttingen · DECentre Hospitalier Universitaire de Nice · FRFondazione IRCCS Istituto Neurologico Carlo Besta · ITGhent University Hospital · BEGuy's and St Thomas' NHS Foundation Trust · GBUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Bari Aldo Moro · ITUniversity of Copenhagen · DKUniversity of Liège · BEUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The medical treatment of patients with chronic primary headache syndromes (chronic migraine, chronic tension-type headache, chronic cluster headache, hemicrania continua) is challenging as serious side effects frequently complicate the course of medical treatment and some patients may be even medically intractable. When a definitive lack of responsiveness to conservative treatments is ascertained and medication overuse headache is excluded, neuromodulation options can be considered in selected cases. Here, the various invasive and non-invasive approaches, such as hypothalamic deep brain stimulation, occipital nerve stimulation, stimulation of sphenopalatine ganglion, cervical spinal cord stimulation, vagus nerve stimulation, transcranial direct current stimulation, repetitive transcranial magnetic stimulation, and transcutaneous electrical nerve stimulation are extensively published although proper RCT-based evidence is limited. The European Headache Federation herewith provides a consensus statement on the clinical use of neuromodulation in headache, based on theoretical background, clinical data, and side effect of each method. This international consensus further gives recommendations for future studies on these new approaches. In spite of a growing field of stimulation devices in headaches treatment, further controlled studies to validate, strengthen and disseminate the use of neurostimulation are clearly warranted. Consequently, until these data are available any neurostimulation device should only be used in patients with medically intractable syndromes from tertiary headache centers either as part of a valid study or have shown to be effective in such controlled studies with an acceptable side effect profile.

Indexed as

Chronic PainDeep Brain StimulationElectric Stimulation TherapyHeadacheHeadache DisordersHumansTranscranial Magnetic Stimulation

Identifiers

PMID24144382
PMCPMC4231359
OpenAlexW2158520507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.