ArticleJournal of neuroinflammation2013
TSG (2,3,4' ,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia.
Article in Journal of neuroinflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review.Journal of ethnopharmacology · 2015Pooled it
- Metabolomic analysis revealed the edible and extended-application potential of specificHeliyon · 2024Article
- 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Attenuates Reactive Oxygen Species-Dependent Inflammation and Apoptosis inAntioxidants (Basel, Switzerland) · 2022Article
- Effects of Uremic Clearance Granules on p38 MAPK/NF-κB Signaling Pathway, Microbial and Metabolic Profiles in End-Stage Renal Disease Rats Receiving Peritoneal Dialysis.Drug design, development and therapy · 2022Article
- 2,3,5,4'-Tetrahydroxystilbene-2-Frontiers in cell and developmental biology · 2022Article
- TSG Targeting KDM5A Affects Osteogenic Differentiation of Bone Mesenchymal Stem Cells Induced by Bone Morphogenetic Protein 2.Journal of healthcare engineering · 2022Article
- Herb-Induced Liver Injury Related toFrontiers in pharmacology · 2021Review
- Otoprotective Effect of 2,3,4',5-Tetrahydroxystilbene-2-Molecules (Basel, Switzerland) · 2020Article
- Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice.Journal of neuroinflammation · 2020Article
- Protective Effects of 2,3,5,4'-Tetrahydroxystilbene-2-International journal of molecular sciences · 2018Article
- 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.Experimental and therapeutic medicine · 2018Article
- Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss.Journal of neuroinflammation · 2018Article
- HO-1 Is Essential for Tetrahydroxystilbene Glucoside Mediated Mitochondrial Biogenesis and Anti-Inflammation Process in LPS-Treated RAW264.7 Macrophages.Oxidative medicine and cellular longevity · 2017Article
- Arctigenin Confers Neuroprotection Against Mechanical Trauma Injury in Human Neuroblastoma SH-SY5Y Cells by Regulating miRNA-16 and miRNA-199a Expression to Alleviate Inflammation.Journal of molecular neuroscience : MN · 2016Article
- Biological Activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments.Oxidative medicine and cellular longevity · 2016Review
- Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia.Journal of neuroinflammation · 2015Article
- The potential of selected Australian medicinal plants with anti-Proteus activity for the treatment and prevention of rheumatoid arthritis.Pharmacognosy magazine · 2015Article
- The potential of selected South African plants with anti-Klebsiella activity for the treatment and prevention of ankylosing spondylitis.Inflammopharmacology · 2015Article
- PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid β-Induced Cognitive Deficits through Modulation of Neuroinflammation.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInduction of pro-inflammatory factors is one of the characteristics of microglia activation and can be regulated by numerous active components of Chinese traditional herbs. Suppression of pro-inflammatory factors is beneficial to alleviate microglia-mediated cell injury. The present study aims to investigate the effect and possible mechanism of 2,3,4',5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG) on LPS-mediated induction of pro-inflammatory factors in microglia.
methodsWestern blot, ELISA, and Hoechst 33258 were used to measure the protein expression, TNF-α/IL-6 content, and apoptotic nuclei, respectively. The mRNA level was measured by real time-PCR. Nitric oxide (NO) content, lactate dehydrogenase (LDH) content, and NF-κB binding activity were assayed by commercial kits.
resultsTSG reduced iNOS protein expression as well as TNF-α, IL-6, and NO content in LPS-stimulated BV-2 cells. TSG attenuated the increase in apoptotic nuclei, caspase-3 cleavage, and LDH content induced by BV-2 cell-derived conditioned medium in primary hippocampal neurons. Mechanistic studies showed that TSG reduced the mRNA level of iNOS, TNF-α, and IL-6. TSG failed to suppress IκB-α degradation, NF-κB phosphorylation and nuclear translocation, and ERK1/2, JNK, and p38 phosphorylation. TSG, however, markedly reduced the binding of NF-κB to its DNA element. Chromatin immunoprecipitation (ChIP) assays confirmed that TSG reduced NF-κB binding to the iNOS promoter. These findings were ascertained in primary microglia where the LPS-induced increase in iNOS expression, NO content, apoptotic nuclei, and NF-κB binding to its DNA element were diminished by TSG.
conclusionsThese studies demonstrate that TSG attenuates LPS-mediated induction of pro-inflammatory factors in microglia through reducing the binding activity of NF-κB. This might help us to further understand the pharmacological role of TSG in inflammatory response in the central nervous system.
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