Scopolamine and ketamine: evidence of convergence?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Synaptic basis of rapid antidepressant action.European archives of psychiatry and clinical neuroscience · 2025
   Review
2. Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation.Nature neuroscience · 2021
   Article
3. Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
   Review
4. Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine.Neurobiology of stress · 2019
   Article
5. Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development.Neurobiology of stress · 2017
   Review
6. Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine.Current neuropharmacology · 2017
   Review
7. GABA interneurons mediate the rapid antidepressant-like effects of scopolamine.The Journal of clinical investigation · 2016
   Article
8. Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.Molecular psychiatry · 2015
   Review
9. How does ketamine elicit a rapid antidepressant response?Current opinion in pharmacology · 2015
   Review

Corrections and comments

• Comment on
  Ketamine for depression: where do we go from here?2012
• Comment on
  Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats.2013

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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