ArticleDiagnostic pathology2013
Expression of microRNA-497 and its prognostic significance in human breast cancer.
Article in Diagnostic pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis.Disease markers · 2019Pooled it
- Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis.Diagnostic pathology · 2014Pooled it
- Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021Article
- Interplay between p53 and non-coding RNAs in the regulation of EMT in breast cancer.Cell death & disease · 2021Review
- Biological Role and Clinical Implications of microRNAs in BRCA Mutation Carriers.Frontiers in oncology · 2021Review
- Prediction of clusters of miRNA binding sites in mRNA candidate genes of breast cancer subtypes.PeerJ · 2019Article
- Article
- LAMP1 expression is associated with poor prognosis in breast cancer.Oncology letters · 2017Article
- miR-497 expression, function and clinical application in cancer.Oncotarget · 2016Review
- MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes.Oncotarget · 2016Article
- MiR-497 enhances metastasis of oral squamous cell carcinoma through SMAD7 suppression.American journal of translational research · 2016Article
- ApoptomiRs of Breast Cancer: Basics to Clinics.Frontiers in genetics · 2016Review
- MiR-497 promotes metastasis of colorectal cancer cells through Nrdp1 inhibition.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients.International journal of molecular sciences · 2015Article
- Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer.Diagnostic pathology · 2015Article
- Retraction note: Expression of microRNA-497 and its prognostic significance in human breast cancer.Diagnostic pathology · 2015Article
- Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management.Breast cancer research : BCR · 2015Review
- Impact of Nutrition on Non-Coding RNA Epigenetics in Breast and Gynecological Cancer.Frontiers in nutrition · 2015Review
- Down-regulation of miR-497 is associated with poor prognosis in renal cancer.International journal of clinical and experimental pathology · 2015Article
- MicroRNA expression profiling in male and female familial breast cancer.British journal of cancer · 2014Article
Corrections and comments
- Retraction · 2015-03-26Compromised Peer Review · Investigation by Journal/Publisher · Misconduct by Third Party ·
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDysregulation of microRNAs (miRNAs) plays critical roles in tumor progression. The aim of this study was to investigate the clinicopathologic and prognostic significance of miR-497 expression in human breast cancer (BC).
methodsTaqman qRT-PCR assay was performed to detect the expression of microRNA (miR)-497 in 30 pairs of BC tissues and corresponding noncancerous breast tissues. Additionally, the expression of this miRNA was detected in another 128 BC tissues and its correlations with clinicopathologic features of patients were analyzed. Kaplan-Meier analyses were used to assess survival of patients. Univariate and multivariate analyses were performed using the Cox proportional hazards model to analyze the prognostic significance of miR-497 expression.
resultsOur data indicated that the relative level of miR-497 expression in BC tissues was significantly lower than that in corresponding noncancerous breast tissues (P = 0.0046). Of 128 BC patients, 74 (57.8%) were placed in the high-miR-497 group and 54 (42.2%) were placed in the low-miR-497 group. By statistical analyses, low miR-497 expression was observed to be closely correlated with higher differentiation grade, positive HER-2 expression, higher incidence of lymph node metastasis and advanced clinical stage. Moreover, patients with high miR-497 expression had better 5-year disease-free and overall survival compared with the low miR-497 group (P = 0.0124 and 0.0018, respectively). Univariate and multivariate analyses indicated that low miR-497 expression was an independent poor prognostic factor for BC patients.
conclusionsOur data provided the first evidence that downregulation of miR-497 was correlated with BC progression, and miR-497 might be a potential molecular biomarker for predicting the prognosis of patients. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2025828761093488.
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