ArticleBiology open2013
Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth.
Article in Biology open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Potassium channels in cancer: from hallmarks to therapeutic targeting.Journal of physiology and biochemistry · 2026Review
- Thiazole-Substituted Benzoylpiperazines with Anti-Cancer and Anti-Inflammatory Activities: Comparative Evaluation with Lercanidipine.International journal of molecular sciences · 2026Article
- The T-type calcium channelosome.Pflugers Archiv : European journal of physiology · 2024Review
- CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation.Scientific reports · 2023Article
- The Role οf Ion Channels in the Development and Progression of Prostate Cancer.Molecular diagnosis & therapy · 2023Review
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- Orai1 Boosts SK3 Channel Activation.Cancers · 2021Article
- Repositioning Trimebutine Maleate as a Cancer Treatment Targeting Ovarian Cancer Stem Cells.Cells · 2021Article
- Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening.Reviews of physiology, biochemistry and pharmacology · 2021Review
- Molecular Choreography and Structure of CaMembranes · 2020Review
- Review
- Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership.Scientific reports · 2019Article
- T-type Calcium Channels in Cancer.Cancers · 2019Review
- Constitutive calcium entry and cancer: updated views and insights.European biophysics journal : EBJ · 2017Review
- The calcium-cancer signalling nexus.Nature reviews. Cancer · 2017Review
- Evolutionary insights into T-type CaThe Journal of general physiology · 2017Article
- CaEuropean biophysics journal : EBJ · 2016Review
- BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK.Oncotarget · 2016Article
- The voltage gated Ca(2+)-channel Cav3.2 and therapeutic responses in breast cancer.Cancer cell international · 2016Article
- Article
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Authors and funding
11 authors.
Funding
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Abstract
It is strongly suspected that potassium (K(+)) channels are involved in various aspects of prostate cancer development, such as cell growth. However, the molecular nature of those K(+) channels implicated in prostate cancer cell proliferation and the mechanisms through which they control proliferation are still unknown. This study uses pharmacological, biophysical and molecular approaches to show that the main voltage-dependent K(+) current in prostate cancer LNCaP cells is carried by large-conductance BK channels. Indeed, most of the voltage-dependent current was inhibited by inhibitors of BK channels (paxillin and iberiotoxin) and by siRNA targeting BK channels. In addition, we reveal that BK channels constitute the main K(+) channel family involved in setting the resting membrane potential in LNCaP cells at around -40 mV. This consequently promotes a constitutive calcium entry through T-type Cav3.2 calcium channels. We demonstrate, using single-channel recording, confocal imaging and co-immunoprecipitation approaches, that both channels form macromolecular complexes. Finally, using flow cytometry cell cycle measurements, cell survival assays and Ki67 immunofluorescent staining, we show that both BK and Cav3.2 channels participate in the proliferation of prostate cancer cells.
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