ArticlePloS one2013
The Scutellaria baicalensis R2R3-MYB transcription factors modulates flavonoid biosynthesis by regulating GA metabolism in transgenic tobacco plants.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- SbLOX3 modulates jasmonate-associated flavonoid accumulation, root growth, and drought-induced root hollow formation inFrontiers in plant science · 2026Article
- Sbmyb111 act as a transcriptional activator of flavonoid synthesis in Scutellaria baicalensis.Plant molecular biology · 2025Article
- Transcriptome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2024Article
- Effects of elicitors from culture filtrate ofFrontiers in plant science · 2024Article
- SbMYB3 transcription factor promotes root-specific flavone biosynthesis inHorticulture research · 2023Article
- Integrated network analyses identify MYB4R1 neofunctionalization in the UV-B adaptation of Tartary buckwheat.Plant communications · 2022Article
- Phytochemical Profiling and Bio-Potentiality of GenusBiomolecules · 2022Review
- Whole genome and transcriptome reveal flavone accumulation inFrontiers in plant science · 2022Article
- Metabolic Analysis of Root, Stem, and Leaf ofPlants (Basel, Switzerland) · 2021Article
- Function analysis and stress-mediatedPlant signaling & behavior · 2020Article
- Mining genes associated with furanocoumarin biosynthesis in an endangered medicinal plant,Journal of genetics · 2020Article
- DNA Methylation Influences Chlorogenic Acid Biosynthesis inFrontiers in plant science · 2017Article
- Factor Analysis of MYB Gene Expression and Flavonoid Affecting Petal Color in Three Crabapple Cultivars.Frontiers in plant science · 2017Article
- De Novo transcriptome characterization of Dracaena cambodiana and analysis of genes involved in flavonoid accumulation during formation of dragon's blood.Scientific reports · 2016Article
- In silico identification of miRNAs and their target genes and analysis of gene co-expression network in saffron (Molecular biology research communications · 2016Article
- Diversifying selection of the anthocyanin biosynthetic downstream gene UFGT accelerates floral diversity of island Scutellaria species.BMC evolutionary biology · 2016Article
- A Kelch Domain-Containing F-Box Coding Gene Negatively Regulates Flavonoid Accumulation in Muskmelon.Plant physiology · 2015Article
- Exogenous GA₃ Application Enhances Xylem Development and Induces the Expression of Secondary Wall Biosynthesis Related Genes in Betula platyphylla.International journal of molecular sciences · 2015Article
- Comprehensive transcriptome analysis of Crocus sativus for discovery and expression of genes involved in apocarotenoid biosynthesis.BMC genomics · 2015Article
- Positive selection and functional divergence of R2R3-MYB paralogous genes expressed in inflorescence buds of Scutellaria species (Labiatae).International journal of molecular sciences · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
R2R3-MYB proteins play role in plant development, response to biotic and abiotic stress, and regulation of primary and secondary metabolism. Little is known about the R2R3-MYB proteins in Scutellaria baicalensis which is an important Chinese medical plant. In this paper, nineteen putative SbMYB genes were identified from a S. baicalensis cDNA library, and eleven R2R3-MYBs were clustered into 5 subgroups according to phylogenetic reconstruction. In the S. baicalensis leaves which were sprayed with GA3, SbMYB2 and SbMYB7 had similar expression pattern with SbPALs, indicating that SbMYB2 and SbMYB7 might be involved in the flavonoid metabolism. Transactivation assay results showed that SbMYB2 and SbMYB7 can function as transcriptional activator. The expression of several flavonoid biosynthesis-related genes were induced or suppressed by overexpression of SbMYB2 or SbMYB7 in transgenic tobacco plants. Consistent with the change of the expression of NtDH29 and NtCHI, the contents of dicaffeoylspermidine and quercetin-3,7-O-diglucoside in SbMYB2-overexpressing or SbMYB7-overexpressing transgenic tobacco plants were decreased. The transcriptional level of NtUFGT in transgenic tobacco overexpressing SbMYB7 and the transcriptional level of NtHCT in SbMYB2-overexpressing tobacco plants were increased; however the application of GA3 inhibited the transcriptional level of these two genes. These results suggest that SbMYB2 and SbMYB7 might regulate the flavonoid biosynthesis through GA metabolism.
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