ArticlePloS one2013
Periatrial epicardial fat is associated with markers of endothelial dysfunction in patients with atrial fibrillation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Pooled it
- Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- The thrombin receptor PAR4 supports visceral adipose tissue inflammation.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Association of pericoronary adipose tissue with atrial fibrillation recurrence after ablation based on computed tomographic angiography.Japanese journal of radiology · 2023Article
- Effect of Endothelial Adhesion Molecules on Atrial Fibrillation: A Systematic Review and Meta-analysis.Heart international · 2022Review
- Effect of epicardial fat volume on outcomes after left atrial posterior wall isolation in addition to pulmonary vein isolation in patients with persistent atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- WNT signaling in atrial fibrillation.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Is there a relationship between epicardial fat tissue thickness and Tp-Te/QT ratio in healthy individuals?Archives of medical sciences. Atherosclerotic diseases · 2020Article
- Periatrial Fat Quality Predicts Atrial Fibrillation Ablation Outcome.Circulation. Cardiovascular imaging · 2019 · on this mapArticle
- Proteomics and transcriptomics in atrial fibrillation.Herzschrittmachertherapie & Elektrophysiologie · 2018Review
- The impact of obesity on the relationship between epicardial adipose tissue, left ventricular mass and coronary microvascular function.European journal of nuclear medicine and molecular imaging · 2015Article
- Evaluating the Atrial Myopathy Underlying Atrial Fibrillation: Identifying the Arrhythmogenic and Thrombogenic Substrate.Circulation · 2015Review
- Inflammation, a link between obesity and atrial fibrillation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Review
- Association of epicardial and peri-atrial adiposity with the presence and severity of non-valvular atrial fibrillation.The international journal of cardiovascular imaging · 2015Article
- Heart failure and atrial fibrillation: from basic science to clinical practice.International journal of molecular sciences · 2015Review
- Association of epicardial adipose tissue thickness and inflammation parameters with CHA2DS2-VASASc score in patients with nonvalvular atrial fibrillation.Therapeutics and clinical risk management · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpicardial adipose tissue (EAT) is associated to atrial fibrillation (AF) burden and outcome after AF ablation. We intended to determine whether global or local EAT is associated with systemic and/or left atrial (LA) inflammation and markers of endothelial dysfunction in AF patients. METHODS AND
resultsTotal, atrial, and ventricular EAT volume (EAT total, EAT atrial, EAT ventricular) were measured by multislice cardiac CT in 49 patients with paroxysmal (PAF, n=25) or persistent AF (PeF, n=24). Periatrial epicardial fat thickness at the esophagus (LA-ESO) and thoracic aorta (LA-ThA) were also measured. Vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), soluble intercellular adhesion molecule 1 (sICAM-1), transforming growth factor-β1 (TGF-β1), and von Willebrand Factor (vWF) levels were measured in peripheral and LA blood samples obtained during catheterization during AF ablation. Patients with PeF had higher EAT atrial (P<0.05) and LA-ESO (P=0.04) than patients with PAF. VEGF, IL-8, and TGF-β1 were not associated with EAT. In contrast, after adjusting for LA volume and body mass index, higher LA-ThA was significantly associated with higher sICAM-1 and vWF levels, both in peripheral blood (P<0.05) and in LA (P<0.05). Similar results were found with LA-ESO. Body mass index, EAT total and EAT ventricular were not associated with sICAM-1 and vWF.
conclusionsPeriatrial epicardial fat showed a significant positive association with increased levels of sICAM-1 and vWF, which are biomarkers of endothelial dysfunction. No such associations were found when considering body mass index or EAT total. These results suggest that local EAT rather than regional or total adiposity may modulate endothelial dysfunction in patients with AF.
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