ArticlePloS one2013
Long-term functional outcomes and correlation with regional brain connectivity by MRI diffusion tractography metrics in a near-term rabbit model of intrauterine growth restriction.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Neurobehavioural outcomes after term IUGR from adolescence to adulthood: a cross-species scoping review.Pediatric research · 2026Review
- Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function.Brain pathology (Zurich, Switzerland) · 2025Article
- Development of a New Scoring System in Higher Animals for Testing Cognitive Function in the Newborn Period: Effect of Prenatal Hypoxia-Ischemia.Developmental neuroscience · 2025Article
- Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone.Frontiers in molecular neuroscience · 2024Article
- Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model.Scientific reports · 2023Article
- Fetal Growth Restriction Impairs Lung Function and Neurodevelopment in an Early Preterm Rabbit Model.Biomedicines · 2023Article
- Excitatory and inhibitory neuron imbalance in the intrauterine growth restricted fetal guinea pig brain: Relevance to the developmental origins of schizophrenia and autism.Developmental neurobiology · 2023Article
- Severe intraventricular hemorrhage causes long-lasting structural damage in a preterm rabbit pup model.Pediatric research · 2022Article
- Docosahexaenoic Acid and Melatonin Prevent Impaired Oligodendrogenesis Induced by Intrauterine Growth Restriction (IUGR).Biomedicines · 2022Article
- Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit ModelsFrontiers in toxicology · 2022Article
- Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction.Stem cells translational medicine · 2021Article
- Earlier preterm birth is associated with a worse neurocognitive outcome in a rabbit model.PloS one · 2021Article
- Nutritional intra-amniotic therapy increases survival in a rabbit model of fetal growth restriction.PloS one · 2018Article
- Neonatal and Long-Term Consequences of Fetal Growth Restriction.Current pediatric reviews · 2018Review
- Article
- Detection and assessment of brain injury in the growth-restricted fetus and neonate.Pediatric research · 2017Review
- Competition for Materno-Fetal Resource Partitioning in a Rabbit Model of Undernourished Pregnancy.PloS one · 2017Article
- The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome.The Journal of physiology · 2016Review
- Is the ferret a suitable species for studying perinatal brain injury?International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2015Review
- Quantitative Evaluation of Rabbit Brain Injury after Cerebral Hemisphere Radiation Exposure Using Generalized q-Sampling Imaging.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntrauterine growth restriction (IUGR) affects 5-10% of all newborns and is associated with increased risk of memory, attention and anxiety problems in late childhood and adolescence. The neurostructural correlates of long-term abnormal neurodevelopment associated with IUGR are unknown. Thus, the aim of this study was to provide a comprehensive description of the long-term functional and neurostructural correlates of abnormal neurodevelopment associated with IUGR in a near-term rabbit model (delivered at 30 days of gestation) and evaluate the development of quantitative imaging biomarkers of abnormal neurodevelopment based on diffusion magnetic resonance imaging (MRI) parameters and connectivity. METHODOLOGY: At +70 postnatal days, 10 cases and 11 controls were functionally evaluated with the Open Field Behavioral Test which evaluates anxiety and attention and the Object Recognition Task that evaluates short-term memory and attention. Subsequently, brains were collected, fixed and a high resolution MRI was performed. Differences in diffusion parameters were analyzed by means of voxel-based and connectivity analysis measuring the number of fibers reconstructed within anxiety, attention and short-term memory networks over the total fibers. PRINCIPAL
findingsThe results of the neurobehavioral and cognitive assessment showed a significant higher degree of anxiety, attention and memory problems in cases compared to controls in most of the variables explored. Voxel-based analysis (VBA) revealed significant differences between groups in multiple brain regions mainly in grey matter structures, whereas connectivity analysis demonstrated lower ratios of fibers within the networks in cases, reaching the statistical significance only in the left hemisphere for both networks. Finally, VBA and connectivity results were also correlated with functional outcome.
conclusionsThe rabbit model used reproduced long-term functional impairments and their neurostructural correlates of abnormal neurodevelopment associated with IUGR. The description of the pattern of microstructural changes underlying functional defects may help to develop biomarkers based in diffusion MRI and connectivity analysis.
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