ArticlePloS one2013
Heterogeneity among orf virus isolates from goats in Fujian Province, Southern China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Molecular Detection and Characterization of Orf Virus in Goats With Clinical Signs From Four Districts of Tanzania.Veterinary medicine and science · 2026Article
- Contagious ecthyma in small ruminants: from etiology to vaccine challenges - a review.Veterinary research communications · 2025Review
- A rare case of human infection with Orf virus in China, 2024.Frontiers in cellular and infection microbiology · 2025Article
- Molecular detection and phylogenetic analysis of Orf viruses from goats in Jiangxi province, China.Frontiers in veterinary science · 2024Article
- An evaluation of the ecological niche of Orf virus (Poxviridae): Challenges of distinguishing broad niches from no niches.PloS one · 2024Article
- Genetic Analysis of Orf Virus (ORFV) Strains Isolated from Goats in China: Insights into Epidemiological Characteristics and Evolutionary Patterns.Virus research · 2023Article
- Genome-Wide Analysis and Molecular Characterization of Orf Virus Strain UPM/HSN-20 Isolated From Goat in Malaysia.Frontiers in microbiology · 2022Article
- A Review on Human Orf: A Neglected Viral Zoonosis.Research and reports in tropical medicine · 2021Review
- An association of Orf virus infection among sheep and goats with herd health programme in Terengganu state, eastern region of the peninsular Malaysia.BMC veterinary research · 2019Article
- Transcriptomic profiles of human foreskin fibroblast cells in response to orf virus.Oncotarget · 2017Article
- The whole genomic analysis of orf virus strain HN3/12 isolated from Henan province, central China.BMC veterinary research · 2017Article
- Seroprevalence of contagious ecthyma in goats of Assam: An analysis by indirect enzyme-linked immunosorbent assay.Veterinary world · 2016Article
- Phylogenetic analysis of three orf virus strains isolated from different districts in Shandong Province, East China.The Journal of veterinary medical science · 2016Article
- Identification and Characterization of a Cleavage Site in the Proteolysis of Orf Virus 086 Protein.Frontiers in microbiology · 2016Article
- Isolation and phylogenetic analysis of caprine Orf virus in Malaysia.Virusdisease · 2015Article
- Isolation and Characterization of Monoclonal Antibodies Against a Virion Core Protein of Orf Virus Strain NA1/11 As Potential Diagnostic Tool for Orf Viruses.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2015Article
- Genome analysis of orf virus isolates from goats in the Fujian Province of southern China.Frontiers in microbiology · 2015Article
- Isolation and phylogenetic analysis of an orf virus from sheep in Makhdoom, India.Virus genes · 2014Article
- A survey of contagious ecthyma and molecular characterization of Orf virus in sheep and goats in Nigeria (2014-2016).Open veterinary journalArticle
- Molecular detection and characterization of Orf virus from goats in Egypt.Open veterinary journalArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orf virus is a parapoxvirus that causes recurring contagious ecthyma or orf disease in goat, sheep and other wild and domestic ruminants. Infected animals show signs of pustular lesions on the mouth and muzzle and develop scabs over the lesions. Although the infection is usually cleared within 1-2 months, delayed growth and associated secondary infections could still impact the herds. Orf virus can also infect humans, causing lesions similar to the animals in pathological histology. Prior infection of orf virus apparently offers little protective immunity against future infections. Several gene products of orf virus have been identified as responsible for immunomodulatory functions. In our recent study of orf virus isolates from an area along the Minjiang River in northern Fujian Province, we found a high heterogeneity among isolates from 10 farms within a 120-kilometer distance. Only two isolates from locations within 1 km to each other had same viral genes. There is no correlation between the geographical distance between the corresponding collection sites and the phylogenetic distance in ORFV011 or ORV059 genes for any two isolates. This finding suggests that there are diverse populations of orf virus present in the environment. This may in part contribute to the phenomenon of recurring outbreaks and heighten the need for better surveillance.
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