ArticleBiomicrofluidics2012
Hand-powered microfluidics: A membrane pump with a patient-to-chip syringe interface.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- A practical microfluidic pump enabled by acoustofluidics and 3D printing.Microfluidics and nanofluidics · 2021Article
- Multifunctional microfluidic chip for optical nanoprobe based RNA detection - application to Chronic Myeloid Leukemia.Scientific reports · 2018Article
- A Controllable and Integrated Pump-enabled Microfluidic Chip and Its Application in Droplets Generating.Scientific reports · 2017Article
- Characterizing the Deformation of the Polydimethylsiloxane (PDMS) Membrane for Microfluidic System through Image Processing.Micromachines · 2016Article
- Balloon Pump with Floating Valves for Portable Liquid Delivery.Micromachines · 2016Article
- On-chip actuation transmitter for enhancing the dynamic response of cell manipulation using a macro-scale pump.Biomicrofluidics · 2015Article
- Osmosis-based pressure generation: dynamics and application.PloS one · 2014Article
- Paper pump for passive and programmable transport.Biomicrofluidics · 2013Article
- A microfluidic device for simultaneous measurement of viscosity and flow rate of blood in a complex fluidic network.Biomicrofluidics · 2013Article
- Microfluidic rectifier based on poly(dimethylsiloxane) membrane and its application to a micropump.Biomicrofluidics · 2013Article
- Field tested milliliter-scale blood filtration device for point-of-care applications.Biomicrofluidics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we present an on-chip hand-powered membrane pump using a robust patient-to-chip syringe interface. This approach enables safe sample collection, sample containment, integrated sharps disposal, high sample volume capacity, and controlled downstream flow with no electrical power requirements. Sample is manually injected into the device via a syringe and needle. The membrane pump inflates upon injection and subsequently deflates, delivering fluid to downstream components in a controlled manner. The device is fabricated from poly(methyl methacrylate) (PMMA) and silicone, using CO2 laser micromachining, with a total material cost of ∼0.20 USD/device. We experimentally demonstrate pump performance for both deionized (DI) water and undiluted, anticoagulated mouse whole blood, and characterize the behavior with reference to a resistor-capacitor electrical circuit analogy. Downstream output of the membrane pump is regulated, and scaled, by connecting multiple pumps in parallel. In contrast to existing on-chip pumping mechanisms that typically have low volume capacity (∼5 μL) and sample volume throughput (∼1-10 μl/min), the membrane pump offers high volume capacity (up to 240 μl) and sample volume throughput (up to 125 μl/min).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.