ArticleClinical interventions in aging2013
Is the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation useful for glomerular filtration rate estimation in the elderly?
Article in Clinical interventions in aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Glomerular filtration rate by different measures and albuminuria are associated with risk of frailty: the Rugao Longitudinal Ageing Study.Aging clinical and experimental research · 2022Article
- Comparison of Creatinine and Cystatin C to Estimate Renal Function in Geriatric and Frail Patients.Life (Basel, Switzerland) · 2022Article
- Assessment of creatinine and cystatin C-based eGFR equations in Chinese older adults with chronic kidney disease.International urology and nephrology · 2018Article
- Clinical factors increasing discrepancies of renal function assessment with MDRD and Cockcroft-Gault equations in old individuals.European geriatric medicine · 2018Article
- CKD-EPI creatinine-cystatin C glomerular filtration rate estimation equation seems more suitable for Chinese patients with chronic kidney disease than other equations.BMC nephrology · 2017Article
- Performance of the creatinine and cystatin C-based equations for estimation of GFR in Chinese patients with chronic kidney disease.Clinical and experimental nephrology · 2017Article
- Performance of cystatin C- and creatinine-based estimated glomerular filtration rate equations depends on patient characteristics.Clinical chemistry · 2015Article
- Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese.Clinical interventions in aging · 2014Article
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8 authors.
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Abstract
backgroundWe aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C equation in a cohort of elderly Chinese participants. MATERIALS AND
methodsGlomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) renal dynamic imaging method, and was calibrated equally to the dual plasma sample (99m)Tc-DTPA-GFR. Performance of the CKD-EPI creatinine-cystatin C equation was compared with the Cockcroft-Gault equation, the re-expressed 4-variable Modification of Diet in Renal Disease (MDRD) equation, and the CKD-EPI creatinine equation.
resultsAlthough the bias of the CKD-EPI creatinine-cystatin C equation was greater than with the other equations (median difference, 5.7 mL/minute/1.73 m(2) versus a range from 0.4-2.5 mL/minute/1.73 m(2); P<0.001 for all), the precision was improved with the CKD-EPI creatinine-cystatin C equation (interquartile range for the difference, 19.5 mL/minute/1.73 m(2) versus a range from 23.0-23.6 mL/minute/1.73 m(2); P<0.001 for all comparisons), leading to slight improvement in accuracy (median absolute difference, 10.5 mL/minute/1.73 m(2) versus 12.2 and 11.4 mL/minute/1.73 m(2) for the Cockcroft-Gault equation and the re-expressed 4-variable MDRD equation, P=0.04 for both; 11.6 mL/minute/1.73 m(2) for the CKD-EPI creatinine equation, P=0.11), as the optimal scores of performance (6.0 versus a range from 1.0-2.0 for the other equations). Higher GFR category and diabetes were independent factors that negatively correlated with the accuracy of the CKD-EPI creatinine-cystatin C equation (β=-0.184 and -0.113, P<0.001 and P=0.02, respectively).
conclusionCompared with the creatinine-based equations, the CKD-EPI creatinine-cystatin C equation is more suitable for the elderly Chinese population. However, the cost-effectiveness of the CKD-EPI creatinine-cystatin C equation for clinical use should be considered.
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