Trial reportOccupational and environmental medicine2013
Endotoxin in concentrated coarse and fine ambient particles induces acute systemic inflammation in controlled human exposures.
Trial report in Occupational and environmental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Trial
- Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study.Environment international · 2017Trial
- B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures.Hypertension (Dallas, Tex. : 1979) · 2015Trial
- Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: a controlled human exposure study.Environmental health perspectives · 2015Trial
- Decreased pulmonary function in school children in Western Japan after exposures to Asian desert dusts and its association with interleukin-8.BioMed research international · 2015Trial
- Association Between Oxidative Potential of Particulate Matter Collected by Personal Samplers and Systemic Inflammation Among Asthmatic and Non-Asthmatic Adults.Antioxidants (Basel, Switzerland) · 2024Article
- Club Cells-A Guardian against Occupational Hazards.Biomedicines · 2023Review
- White and brown adipose tissue functionality is impaired by fine particulate matter (PMJournal of molecular medicine (Berlin, Germany) · 2022Review
- The association between fine particulate matter and acute lower respiratory infections in Yancheng City, China.Environmental science and pollution research international · 2021Article
- An Investigation of Airborne Bioaerosols and Endotoxins Present in Indoor Traditional Wet Markets before and after Operation in Taiwan: A Case Study.International journal of environmental research and public health · 2021Article
- Characterization of inhalable endotoxin, glucan, and dust exposures in Iowa farmers.International journal of hygiene and environmental health · 2020Article
- Associations between Coarse Particulate Matter Air Pollution and Cause-Specific Mortality: A Nationwide Analysis in 272 Chinese Cities.Environmental health perspectives · 2019Article
- Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study.Environment international · 2018Article
- Fine and Coarse Particulate Matter Exposures and Associations with Acute Cardiac Events among Participants in a Telemedicine Service: A Case-Crossover Study.Environmental health perspectives · 2018Article
- Coarse particulate matter (PMScientific reports · 2018Article
- Long-Term Coarse Particulate Matter Exposure Is Associated with Asthma among Children in Medicaid.American journal of respiratory and critical care medicine · 2018Article
- Ovarian Damages Produced by Aerosolized Fine Particulate Matter (PMChinese medical journal · 2017Article
- B-vitamin Supplementation Mitigates Effects of Fine Particles on Cardiac Autonomic Dysfunction and Inflammation: A Pilot Human Intervention Trial.Scientific reports · 2017Article
- Long-Term Exposure to Traffic-Related Air Pollution and Risk of Incident Atrial Fibrillation: A Cohort Study.Environmental health perspectives · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundKnowledge of the inhalable particulate matter components responsible for health effects is important for developing targeted regulation.
objectivesIn a double-blind randomised cross-over trial of controlled human exposures to concentrated ambient particles (CAPs) and their endotoxin and (1→3)-β-D-glucan components, we evaluated acute inflammatory responses.
methods35 healthy adults were exposed to five 130-min exposures at rest: (1) fine CAPs (~250 µg/m(3)); (2) coarse CAPs (200 µg/m(3)); (3) second coarse CAPs (~200 µg/m(3)); (4) filtered air; and (5) medical air. Induced sputum cell counts were measured at screening and 24 h postexposure. Venous blood total leucocytes, neutrophils, interleukin-6 and high-sensitivity C reactive protein (CRP) were measured pre-exposure, 3 and 24 h postexposure.
resultsRelative to filtered air, an increase in blood leucocytes 24 h (but not 3 h) postexposure was significantly associated with coarse (estimate=0.44×10(9) cells/L (95% CI 0.01 to 0.88); n=132) and fine CAPs (0.68×10(9) cells /L (95% CI 0.19 to 1.17); n=132), but not medical air. Similar associations were found with neutrophil responses. An interquartile increase in endotoxin (5.4 ng/m(3)) was significantly associated with increased blood leucocytes 3 h postexposure (0.27×10(9) cells/L (95% CI 0.03 to 0.51); n=98) and 24 h postexposure (0.37×10(9) cells/L (95% CI 0.12 to 0.63); n=98). This endotoxin effect did not differ by particle size. There were no associations with glucan concentrations or interleukin-6, CRP or sputum responses.
conclusionsIn healthy adults, controlled coarse and fine ambient particle exposures independently induced acute systemic inflammatory responses. Endotoxin contributes to the inflammatory role of particle air pollution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.