ArticleGenetics2014
Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Wolbachia-mediated reduction in the glutamate receptor mGluR promotes female promiscuity and bacterial spread.Cell reports · 2025Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Review
- Integrative single-cell characterization of a frugivorous and an insectivorous bat kidney and pancreas.Nature communications · 2024Article
- Neural Control of Action Selection Among Innate Behaviors.Neuroscience bulletin · 2022Review
- The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.Cell & bioscience · 2022Review
- Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions.Open biology · 2022Review
- Article
- Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression.Cellular and molecular life sciences : CMLS · 2022Review
- The Neuromodulatory Basis of Aggression: Lessons From the Humble Fruit Fly.Frontiers in behavioral neuroscience · 2022Review
- Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction.PLoS genetics · 2021Article
- Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila.Environmental science and pollution research international · 2020Article
- A single-cell transcriptomic atlas of the adulteLife · 2020Article
- The neuropeptide Drosulfakinin regulates social isolation-induced aggression inThe Journal of experimental biology · 2020Article
- Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila.Nature communications · 2019Article
- The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception.Cell reports · 2018Article
- Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Octopamine Shifts the Behavioral Response From Indecision to Approach or Aversion inFrontiers in behavioral neuroscience · 2018Article
- Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters inFrontiers in cellular neuroscience · 2018Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, the monoamine octopamine, through mechanisms that are not completely understood, regulates both aggression and mating behavior. Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine β-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine production and secretion. Furthermore, we reveal that octopamine in turn regulates aggression through the Drosophila cholecystokinin satiation hormone homolog Drosulfakinin (Dsk). Finally, we establish that TfAP-2 is expressed in octopaminergic neurons known to control aggressive behavior and that TfAP-2 requires functional Twz for its activity. We conclude that genetically manipulating the obesity-linked homologs TfAP-2 and Twz is sufficient to affect octopamine signaling, which in turn modulates Drosophila male behavior through the regulation of the satiation hormone Dsk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.