ArticleCancer2014
The role of adjuvant radiotherapy in the local management of desmoplastic melanoma.
Article in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- Results of NCCTG N0275 (Alliance) - a phase II trial evaluating resection followed by adjuvant radiation therapy for patients with desmoplastic melanoma.Cancer medicine · 2016Trial
- The Role of Adjuvant Primary Site Radiotherapy for Cutaneous Melanoma Patients with Microsatellitosis.Annals of surgical oncology · 2026Article
- Article
- Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma.Cancer reports (Hoboken, N.J.) · 2025Article
- Article
- Article
- Radiation and Melanoma: Where Are We Now?Current oncology reports · 2024Review
- Clinical Characteristics and Special Considerations in the Management of Rare Melanoma Subtypes.Cancers · 2024Review
- Joinpoint regression analysis of recent trends in desmoplastic malignant melanoma incidence and mortality: 15-year multicentre retrospective study.Archives of dermatological research · 2024Article
- Factors associated with the use of adjuvant radiation therapy in stage III melanoma.Frontiers in oncology · 2023Article
- 3D printed integrated bolus/headrest for radiation therapy for malignancies involving the posterior scalp and neck.3D printing in medicine · 2022Article
- Desmoplastic Melanoma: A Clinicopathological Analysis of Three Cases in the Chinese Population.OncoTargets and therapy · 2021Article
- Collective cancer invasion forms an integrin-dependent radioresistant niche.The Journal of experimental medicine · 2020Article
- Desmoplastic melanoma involving head and fingers: diagnostic challenges and clinical characteristics.International journal of clinical and experimental pathology · 2019Article
- Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy-From Animal Models to Clinical Trials.International journal of molecular sciences · 2018Review
- Observational
- Mixed Versus Pure Variants of Desmoplastic Melanoma: The Cleveland Clinic Experience.Annals of plastic surgery · 2018Article
- Neurotropic melanoma: an analysis of the clinicopathological features, management strategies and survival outcomes for 671 patients treated at a tertiary referral center.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Late-Developing Metastatic Malignant Melanoma in the Thoracic Spine Originating from Choroidal Melanoma.Korean Journal of Spine · 2017Article
- A retrospective analysis of the role of adjuvant radiotherapy in the treatment of cutaneous melanoma.Cancer biology & therapy · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn the current study, the authors sought to evaluate outcomes, specifically with respect to adjuvant radiotherapy (RT), for patients with desmoplastic melanoma.
methodsThe records of 130 consecutive patients who presented between 1985 and 2009 with nonmetastatic desmoplastic melanoma and were treated curatively with either surgery alone (59 patients; 45%) or surgery and postoperative RT (71 patients; 55%) were retrospectively reviewed. Ages ranged from 21 years to 97 years (median age, 66 years). The location of the primary tumor was in the head and neck region in 62% of patients. Only 5 patients (4%) had lymph node involvement at the time of presentation.
resultsThe median follow-up was 6.6 years (range, 11 months-24 years). Overall survival rates at 5 years and 10 years were 69% and 53%, respectively. Disease-specific survival rates were 84% and 80%, respectively, at 5 years and 10 years. The actuarial rate of local recurrence was 17% at 5 years and beyond. Of the patients who underwent surgery without receiving postoperative RT, 14 (24%) experienced local recurrence. Of the 71 patients treated with surgery and postoperative RT, 5 (7%) experienced local recurrence. In a Cox multivariate regression model, improved local control was significantly associated with the receipt of postoperative RT (P= .009).
conclusionsSurgery followed by postoperative RT appears to provide superior local control compared with surgery alone for patients with desmoplastic melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.