SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Tumor Necrosis Factor-α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis.Journal of gastrointestinal cancer · 2022Pooled it
- Pooled it
- Association between PSCA, TNF-α, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike.World journal of gastrointestinal oncology · 2016Review
- Clinical significance of serum interleukin-29, interleukin-32, and tumor necrosis factor alpha levels in patients with gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Effect of expressions of tumor necrosis factor α and interleukin 1B on peritoneal metastasis of gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Effect of three common IL-17 single nucleotide polymorphisms on the risk of developing gastric cancer.Oncology letters · 2015Article
- Lack of association among TNF-α gene expression, -308 polymorphism (G > A) and virulence markers of Helicobacter pylori.The journal of venomous animals and toxins including tropical diseases · 2015Article
- Exploratory Analysis of VEGF Polymorphisms and Colorectal Cancer Risk in a Hungarian Population: A Case-Control Study.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer is mainly initiated by inflammation and chronic superficial gastritis, and tumor necrosis factor-α (TNF-α) is an inflammatory cytokine which plays an important role in the inflammation. TNF-α rs1800629 G/A polymorphism was proposed to be associated with gastric cancer risk, but previous studies on Caucasians reported conflicting results. We performed a meta-analysis to comprehensively assess the association between TNF-α rs1800629 polymorphism and gastric cancer risk in Caucasians. The pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the association. Eleven case-control studies with 7,427 subjects were finally included into the meta-analysis. Overall, TNF-α rs1800629 polymorphism was significantly associated with the increased risk of gastric cancer under four genetic comparison models (A versus G: OR = 1.32, 95% CI 1.12-1.56, P = 0.001; AA versus GG: OR = 1.76, 95% CI 1.37-2.26, P < 0.001; AA versus GG/GA: OR = 1.62, 95% CI 1.27-2.07, P < 0.001; AA/GA versus GG: OR = 1.35, 95% CI 1.14-1.60, P = 0.001). Meta-analysis of those studies with high quality showed that TNF-α rs1800629 polymorphism was still significantly associated with the increased risk of gastric cancer under four genetic comparison models. There was no risk of publication bias in the meta-analysis. The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with the increased risk of gastric cancer in Caucasians.
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