ArticleHuman brain mapping2014
Neural correlates of successful semantic processing during propofol sedation.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Reorganisation of Brain Hubs across Altered States of Consciousness.Scientific reports · 2020Trial
- Disruption of cortical integration during midazolam-induced light sedation.Human brain mapping · 2015Trial
- Effect of propofol on the medial temporal lobe emotional memory system: a functional magnetic resonance imaging study in human subjects.British journal of anaesthesia · 2015Trial
- The neural correlates of shared and individual experience.Communications biology · 2026Article
- The amnesic effects of propofol on functional connectivity in the hippocampus determined by functional magnetic resonance imaging in volunteers.British journal of anaesthesia · 2025Article
- Clinical Diagnostic and Prognostic Value of Residual Language Learning Ability in Patients with Disorders of Consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Connectome harmonic decomposition tracks the presence of disconnected consciousness during ketamine-induced unresponsiveness.British journal of anaesthesia · 2025Article
- Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics.Nature communications · 2024Article
- The effects of propofol anaesthesia on molecular-enriched networks during resting-state and naturalistic listening.NeuroImage · 2023Article
- Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.Communications biology · 2023Article
- The complexity of the stream of consciousness.Communications biology · 2022Article
- Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.Neurocritical care · 2022Article
- Effect of Anesthetics on Functional Connectivity of Developing Brain.Frontiers in human neuroscience · 2022Review
- Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study.Brain injury · 2021Article
- Article
- Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mapping Verb Retrieval With nTMS: The Role of Transitivity.Frontiers in human neuroscience · 2021Article
- Sedation Modulates Frontotemporal Predictive Coding Circuits and the Double Surprise Acceleration Effect.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Brief Mindfulness Meditation Induces Gray Matter Changes in a Brain Hub.Neural plasticity · 2020Article
- Fractal dimension of cortical functional connectivity networks & severity of disorders of consciousness.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Sedation has a graded effect on brain responses to auditory stimuli: perceptual processing persists at sedation levels that attenuate more complex processing. We used fMRI in healthy volunteers sedated with propofol to assess changes in neural responses to spoken stimuli. Volunteers were scanned awake, sedated, and during recovery, while making perceptual or semantic decisions about nonspeech sounds or spoken words respectively. Sedation caused increased error rates and response times, and differentially affected responses to words in the left inferior frontal gyrus (LIFG) and the left inferior temporal gyrus (LITG). Activity in LIFG regions putatively associated with semantic processing, was significantly reduced by sedation despite sedated volunteers continuing to make accurate semantic decisions. Instead, LITG activity was preserved for words greater than nonspeech sounds and may therefore be associated with persistent semantic processing during the deepest levels of sedation. These results suggest functionally distinct contributions of frontal and temporal regions to semantic decision making. These results have implications for functional imaging studies of language, for understanding mechanisms of impaired speech comprehension in postoperative patients with residual levels of anesthetic, and may contribute to the development of frameworks against which EEG based monitors could be calibrated to detect awareness under anesthesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.