ArticleParasitology research2014
Effect of Moringa oleifera lectins on survival and enzyme activities of Aedes aegypti larvae susceptible and resistant to organophosphate.
Article in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 100 citations in OpenAlex.
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- Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains.Journal of applied toxicology : JAT · 2026Article
- Eco-friendly bioactives from Nyctanthes arbor-tristis (L.) for targeted control of Aedes aegypti and Culex quinquefasciatus with reduced impact on Toxorhynchites splendens.Scientific reports · 2025Article
- Phytochemical composition, antioxidant potential, and insecticidal activity of Moringa oleifera extracts against Tribolium castaneum: a sustainable approach to pest management.BMC plant biology · 2025Article
- Insecticidal Activity of Lectin Preparations fromPlants (Basel, Switzerland) · 2025Article
- Carbohydrate-Binding Mechanism of the Coagulant Lectin fromMolecules (Basel, Switzerland) · 2024Article
- Diversity of transgenes in sustainable management of insect pests.Transgenic research · 2023Review
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- Isolation, Purification, and Characterization of Homogenous Novel Bioactive Protein fromJournal of tropical medicine · 2022Article
- Moringa Tree, Gift of Nature: a Review on Nutritional and Industrial Potential.Current pharmacology reports · 2022Review
- Acaricidal activity of the hexanic and hydroethanolic extracts of three medicinal plants against southern cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).Experimental & applied acarology · 2021Article
- Bioefficacy ofMolecules (Basel, Switzerland) · 2021Article
- Bioacaricidal Potential ofPlants (Basel, Switzerland) · 2021Article
- Evaluation of Ethanol Extract ofInsects · 2021Article
- Chemical Composition, Larvicidal Activity, and Enzyme Inhibition of the Essential Oil ofPharmaceuticals (Basel, Switzerland) · 2021Article
- A Review of Resistance Mechanisms of Synthetic Insecticides and Botanicals, Phytochemicals, and Essential Oils as Alternative Larvicidal Agents Against Mosquitoes.Frontiers in physiology · 2019Review
- Development of an eco-friendly mosquitocidal agent from Alangium salvifolium against the dengue vector Aedes aegypti and its biosafety on the aquatic predator.Environmental science and pollution research international · 2018Article
- Toxicological effects of chemical constituents from Piper against the environmental burden Aedes aegypti Liston and their impact on non-target toxicity evaluation against biomonitoring aquatic insects.Environmental science and pollution research international · 2018Article
- Scorpion neurotoxin AaIT-expressing Beauveria bassiana enhances the virulence against Aedes albopictus mosquitoes.AMB Express · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The indiscriminate use of synthetic insecticides to control Aedes aegypti has led to emergence of resistant populations. Moringa oleifera seeds contain the lectins WSMoL and cMoL. WSMoL has larvicidal activity on fourth-stage of A. aegypti organophosphate-susceptible larvae (Rockefeller L4). This study reports on the effects of cMoL on the survival of Rockefeller L4 as well as of WSMoL and cMoL on L4 from an organophosphate-resistant population (Rec-R). The effects of lectins on digestive (amylase, trypsin, and protease) and detoxifying (superoxide dismutase (SOD), α- and β-esterases) enzymes from larvae were also determined. cMoL (0.1-0.8 mg/ml) did not kill Rockefeller L4 as well as WSMoL and cMoL (0.1-0.8 mg/ml) were not larvicidal for Rec-R L4. WSMoL stimulated protease, trypsin-like, and α-amylase from Rockefeller L4 while cMoL inhibited these enzymes. WSMoL had no effect on trypsin-like activity from Rec-R L4 but inhibited protease and α-amylase. Among digestive enzymes of Rec-R L4, cMoL inhibited only trypsin-like activity. cMoL inhibited SOD activities from Rockefeller and Rec-R L4 in a higher level than WSMoL while β-esterase from Rockefeller L4 was more inhibited by WSMoL. The lectins promoted low stimulation or inhibition of α-esterase activities from both populations. In conclusion, Rockefeller and Rec-R larvae were distinctly affected by M. oleifera lectins, and larvicidal mechanism of WSMoL on Rockefeller L4 may involve deregulation of digestive enzymes. cMoL interfered mainly on SOD activity and thus it can be investigated as a synergistic agent for controlling populations whose resistance is linked to an increased detoxifying process mediated by this enzyme.
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