ArticleJournal of bacteriology2014
ubiJ, a new gene required for aerobic growth and proliferation in macrophage, is involved in coenzyme Q biosynthesis in Escherichia coli and Salmonella enterica serovar Typhimurium.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Heterologous plastoquinone production using a newly identified OThe FEBS journal · 2026Article
- Understanding coenzyme Q.Physiological reviews · 2024Review
- Role of themBio · 2023Article
- Rational Engineering of Non-Ubiquinone ContainingMetabolites · 2022Article
- The Biosynthetic Pathway of Ubiquinone Contributes to Pathogenicity of Francisella novicida.Journal of bacteriology · 2021Article
- Revisiting long-chain fatty acid metabolism in Escherichia coli: integration with stress responses.Current genetics · 2021Review
- The EcoCyc Database in 2021.Frontiers in microbiology · 2021Article
- Coenzyme QFrontiers in bioengineering and biotechnology · 2021Article
- PasT of Escherichia coli sustains antibiotic tolerance and aerobic respiration as a bacterial homolog of mitochondrial Coq10.MicrobiologyOpen · 2020Article
- The OThe Journal of biological chemistry · 2020Article
- The Paradox of Coenzyme QNutrients · 2019Review
- Ubiquinone Biosynthesis over the Entire OmBio · 2019Article
- Coenzyme Q biosynthesis in the biopesticide Shenqinmycin-producing Pseudomonas aeruginosa strain M18.Journal of industrial microbiology & biotechnology · 2019Article
- Identification of Genetic Features for Attenuation of TwoFrontiers in veterinary science · 2019Article
- A genome-wide screen inThe Journal of biological chemistry · 2017Article
- Biochemistry of Mitochondrial Coenzyme Q Biosynthesis.Trends in biochemical sciences · 2017Review
- The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.The Journal of biological chemistry · 2017Article
- Chance and necessity in the genome evolution of endosymbiotic bacteria of insects.The ISME journal · 2017Article
- EsrE-AFrontiers in microbiology · 2017Article
- Phenotypic and genetic changes in the life cycle of small colony variants of Salmonella enterica serotype Typhimurium induced by streptomycin.Annals of clinical microbiology and antimicrobials · 2016Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ubiquinone (coenzyme Q or Q8) is a redox active lipid which functions in the respiratory electron transport chain and plays a crucial role in energy-generating processes. In both Escherichia coli and Salmonella enterica serovar Typhimurium, the yigP gene is located between ubiE and ubiB, all three being likely to constitute an operon. In this work, we showed that the uncharacterized yigP gene was involved in Q8 biosynthesis in both strains, and we have renamed it ubiJ. Under aerobic conditions, an ubiJ mutant was found to be impaired for Q8 biosynthesis and for growth in rich medium but did not present any defect anaerobically. Surprisingly, the C-terminal 50 amino acids, predicted to interact with lipids, were sufficient to restore Q8 biosynthesis and growth of the ubiJ mutant. Salmonella ubiE and ubiB mutants were impaired in Q8 biosynthesis and in respiration using different electron acceptors. Moreover, ubiE, ubiJ, and ubiB mutants were all impaired for Salmonella intracellular proliferation in macrophages. Taken together, our data establish an important role for UbiJ in Q8 biosynthesis and reveal an unexpected link between Q8 and virulence. They also emphasize that Salmonella organisms in an intracellular lifestyle rely on aerobic respiration to survive and proliferate within macrophages.
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