ArticleJournal of bacteriology2014
Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Rhizobacteria-Mediated Reprogramming of Phytohormone Landscapes for Mitigating Salinity Stress in Plants.International journal of molecular sciences · 2026Review
- The role of isoprenoids in the chemical interaction between plants and other organisms in their rhizosphere.aBIOTECH · 2025Review
- The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in theOrganic letters · 2025Article
- Discovery of bacterial terpenoids by genome mining.Methods in enzymology · 2025Article
- Gibberellin dynamics governing nodulation revealed using GIBBERELLIN PERCEPTION SENSOR 2 in Medicago truncatula lateral organs.The Plant cell · 2024Article
- Discovery of bifunctional diterpene cyclases/synthases in bacteria supports a bacterial origin for the plant terpene synthase gene family.Horticulture research · 2024Article
- Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structure-guided product determination of the bacterial type II diterpene synthase Tpn2.Communications chemistry · 2022Article
- Production of the plant hormone gibberellin by rhizobia increases host legume nodule size.The ISME journal · 2022Article
- Unraveling a Tangled Skein: Evolutionary Analysis of the Bacterial Gibberellin Biosynthetic Operon.mSphere · 2020Article
- Conserved bases for the initial cyclase in gibberellin biosynthesis: from bacteria to plants.The Biochemical journal · 2019Article
- Gibberellins promote nodule organogenesis but inhibit the infection stages of nodulation.Journal of experimental botany · 2018Article
- A Third Class: Functional Gibberellin Biosynthetic Operon in Beta-Proteobacteria.Frontiers in microbiology · 2018Article
- Genomic features of bacterial adaptation to plants.Nature genetics · 2017Article
- An operon for production of bioactive gibberellin AThe New phytologist · 2017Article
- Characterization of CYP115 As a Gibberellin 3-Oxidase Indicates That Certain Rhizobia Can Produce Bioactive Gibberellin AACS chemical biology · 2017Article
- Investigating the Phylogenetic Range of Gibberellin Biosynthesis in Bacteria.Molecular plant-microbe interactions : MPMI · 2017Article
- Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution.Nature chemical biology · 2017Article
- Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases.PloS one · 2017Article
- Labeling Studies Clarify the Committed Step in Bacterial Gibberellin Biosynthesis.Organic letters · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial interactions with plants are accompanied by complex signal exchange processes. Previously, the nitrogen-fixing symbiotic (rhizo)bacterium Bradyrhizobium japonicum was found to carry adjacent genes encoding two sequentially acting diterpene cyclases that together transform geranylgeranyl diphosphate to ent-kaurene, the olefin precursor to the gibberellin plant hormones. Species from the three other major genera of rhizobia were found to have homologous terpene synthase genes. Cloning and functional characterization of a representative set of these enzymes confirmed the capacity of each genus to produce ent-kaurene. Moreover, comparison of their genomic context revealed that these diterpene synthases are found in a conserved operon which includes an adjacent isoprenyl diphosphate synthase, shown here to produce the geranylgeranyl diphosphate precursor, providing a critical link to central metabolism. In addition, the rest of the operon consists of enzymatic genes that presumably lead to a more elaborated diterpenoid, although the production of gibberellins was not observed. Nevertheless, it has previously been shown that the operon is selectively expressed during nodulation, and the scattered distribution of the operon via independent horizontal gene transfer within the symbiotic plasmid or genomic island shown here suggests that such diterpenoid production may modulate the interaction of these particular symbionts with their host plants.
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