ArticleRevista brasileira de epidemiologia = Brazilian journal of epidemiology2013
Retinol binding protein 4 and incident diabetes--the Atherosclerosis Risk in Communities Study (ARIC Study).
Article in Revista brasileira de epidemiologia = Brazilian journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Retinol binding protein 4 and type 2 diabetes: from insulin resistance to pancreatic β-cell function.Endocrine · 2024Review
- Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2023Article
- Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk.Circulation research · 2022Article
- Sexual Dimorphism in the Association of Serum Retinol-Binding Protein-4 With Long-Term Dynamic Metabolic Profiles in Non-Diabetes.Frontiers in endocrinology · 2022Article
- Retinol, Retinoic Acid, and Retinol-Binding Protein 4 are Differentially Associated with Cardiovascular Disease, Type 2 Diabetes, and Obesity: An Overview of Human Studies.Advances in nutrition (Bethesda, Md.) · 2020Review
- Multiple Biomarkers Improved Prediction for the Risk of Type 2 Diabetes Mellitus in Singapore Chinese Men and Women.Diabetes & metabolism journal · 2020Article
- Retinol binding protein 4 and risk of type 2 diabetes in Singapore Chinese men and women: a nested case-control study.Nutrition & metabolism · 2019Article
- Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure.Cardiorenal medicine · 2018Article
- Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community.Journal of the American Heart Association · 2017Article
- Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundRetinol binding protein 4 (RBP4) has been described as a link between impaired glucose uptake in adipocytes and systemic insulin sensitivity.
objectiveTo determine whether RBP4 fasting levels predict the development of type 2 diabetes.
methodsUsing a case-cohort design, we followed 543 middle-aged individuals who developed diabetes and 537 who did not over ~9 years within the population-based Atherosclerosis Risk in Communities Study. Weighted Cox proportional hazards analyses permitted statistical inference of the RBP4 - incident diabetes associations to the entire cohort.
resultsWomen in the highest tertile of RBP4 presented greater risk of developing diabetes (HR = 1.74; 95%CI 1.03 - 2.94) in analyses adjusted for age, ethnicity, study center, parental history of diabetes, hypertension, glomerular filtration rate, body mass index, waist-hip ratio, nonesterified fatty acids, adiponectin, leptin, triglycerides and HDL-C. When additionally adjusted for fasting insulin, this association's significance became borderline (HR = 1.68; 95%CI 1.00 - 2.82). No association between RBP4 levels and incident diabetes was found in men.
conclusionThese findings suggest that RBP4 levels may be directly involved in the pathogenesis of type 2 diabetes in women.
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