ArticleMemorias do Instituto Oswaldo Cruz2014
Vascular endothelial growth factor-A enhances indoleamine 2,3-dioxygenase expression by dendritic cells and subsequently impacts lymphocyte proliferation.
Article in Memorias do Instituto Oswaldo Cruz, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Smokers or non-smokers: who benefits more from immune checkpoint inhibitors in treatment of malignancies? An up-to-date meta-analysis.World journal of surgical oncology · 2020Pooled it
- Co-phagocytosis of VEGFA with HER2-overexpressing cancer cells induced by HER2-VEGFA-bispecific antibodies improves antitumor responses.JCI insight · 2025Article
- Comparative immunomodulatory properties of mesenchymal stem cells derived from human breast tumor and normal breast adipose tissue.Cancer immunology, immunotherapy : CII · 2020Article
- The landscape of immune cell infiltration and its clinical implications of pancreatic ductal adenocarcinoma.Journal of advanced research · 2020Article
- Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives.International journal of molecular sciences · 2020Review
- The role of indoleamine 2,3 dioxygenase 1 in the osteoarthritis.American journal of translational research · 2020Review
- Current Perspectives in Cancer Immunotherapy.Cancers · 2019Review
- Reverting Immune Suppression to Enhance Cancer Immunotherapy.Frontiers in oncology · 2019Review
- Article
- The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation.Current pathobiology reports · 2018Article
- Re-Emergence of Dendritic Cell Vaccines for Cancer Treatment.Trends in cancer · 2018Review
- Phosphatidylserine-Liposomes Promote Tolerogenic Features on Dendritic Cells in Human Type 1 Diabetes by Apoptotic Mimicry.Frontiers in immunology · 2018Article
- Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast.Clinical, cosmetic and investigational dermatology · 2018Article
- High Indoleamine 2,3-Dioxygenase Is Correlated With Microvessel Density and Worse Prognosis in Breast Cancer.Frontiers in immunology · 2018Article
- Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma.Immunotherapy · 2016Review
- Variations in genes involved in immune response checkpoints and association with outcomes in patients with resected colorectal liver metastases.The pharmacogenomics journal · 2015Article
- Regulation of indoleamine 2,3-dioxygenase in primary human saphenous vein endothelial cells.Journal of inflammation research · 2015Article
- Inhibition of vascular endothelial growth factor by small interfering RNA upregulates differentiation, maturation and function of dendritic cells.Experimental and therapeutic medicine · 2015Article
- The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism.International journal of tryptophan research : IJTR · 2015Review
- Secretion of immunoregulatory cytokines by mesenchymal stem cells.World journal of stem cells · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are antigen (Ag)-presenting cells that activate and stimulate effective immune responses by T cells, but can also act as negative regulators of these responses and thus play important roles in immune regulation. Pro-angiogenic vascular endothelial growth factor (VEGF) has been shown to cause defective DC differentiation and maturation. Previous studies have demonstrated that the addition of VEGF to DC cultures renders these cells weak stimulators of Ag-specific T cells due to the inhibitory effects mediated by VEGF receptor 1 (VEGFR1) and/or VEGFR2 signalling. As the enzyme indoleamine 2,3-dioxygenase (IDO) is recognised as an important negative regulator of immune responses, this study aimed to investigate whether VEGF affects the expression of IDO by DCs and whether VEGF-matured DCs acquire a suppressor phenotype. Our results are the first to demonstrate that VEGF increases the expression and activity of IDO in DCs, which has a suppressive effect on Ag-specific and mitogen-stimulated lymphocyte proliferation. These mechanisms have broad implications for the study of immunological responses and tolerance under conditions as diverse as cancer, graft rejection and autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.