Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015
Synovial cytokine expression in ankle osteoarthritis depends on age and stage.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Association between intraarticular cytokine levels and clinical parameters of osteochondritis dissecans in the ankle.BMC musculoskeletal disorders · 2014Trial
- Biochemical characterization of early osteoarthritis in the ankle.TheScientificWorldJournal · 2014Trial
- Early intra-articular complement activation in ankle fractures.BioMed research international · 2014Trial
- Molecular-biomechanical phenotyping of ankle osteoarthritis: from synovial biomarkers to weight-bearing digital signatures.Frontiers in medicine · 2026Review
- Insights into the bone morphogenetic protein signaling in musculoskeletal disorders: Mechanisms and crosstalk.Journal of orthopaedic translation · 2025Review
- Autologous minced cartilage implantation in osteochondral lesions of the talus-does fibrin make the difference?Archives of orthopaedic and trauma surgery · 2025Article
- Article
- RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis PathogenesisFrontiers in cell and developmental biology · 2021Article
- Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes.Arthritis research & therapy · 2020Article
- Article
- Validation of Activity Tracking Procedures in Elderly Patients after Operative Treatment of Proximal Femur Fractures.Rehabilitation research and practice · 2018Article
- Five-Year Outcomes After Treatment for Acute Instability of the Tibiofibular Syndesmosis Using a Suture-Button Fixation System.Orthopaedic journal of sports medicine · 2017Article
- Osteoarthritis in Football.Cartilage · 2017Article
- Prospective clinical trial of patients who underwent ankle arthroscopy with articular diseases to match clinical and radiological scores with intra-articular cytokines.International orthopaedics · 2015Article
- Prospective Clinical Trial for Septic Arthritis: Cartilage Degradation and Inflammation Are Associated with Upregulation of Cartilage Metabolites.Mediators of inflammationArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAim of the study was the analysis of cytokine expression in ankle osteoarthritis (OA) hypothesizing age-dependent regulation patterns.
methodsForty-nine patients undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial comparing the group <18 years (n = 9, Ø15.1 ± 2.0 years) with the older patients (≥18 years, n = 40, Ø36.5 ± 11.9). Lavage fluids were analysed by ELISA for levels of aggrecan, BMP-2/7, IGF-1/R, bFGF, CD105, MMP-13, and IL-1β. Additionally, clinical parameters and scores (FFI, CFSS, AOFAS) were evaluated and supplemented by radiographic scores [Kellgren-Lawrence Score (KLS) for conventional X-rays, Ankle Osteoarthritis Scoring System (AOSS) for MRI].
resultsIn contrast to distribution of gender and BMI (p < 0.005), parameters characterizing the cartilage defect as ICRS grading, size, and duration of symptoms were not dependent on age. The incidence of osteochondritis dissecans (OCD) was higher in the group <18 years (p < 0.006), but the average degree of OCD grading was not different. KLS and AOSS were significantly higher in the group ≥18 years (p < 0.02). Correlating with the higher degree of OA in the elderly, clinical function measured by FFI and AOFAS was statistically significantly worse (p < 0.05). Intra-articular concentrations of aggrecan (3.1-fold), bFGF (8.7-fold), BMP-7 (2.7-fold), and CD105 (1.5-fold) were statistically significantly higher in the group ≥18 years (p < 0.03).
conclusionsConfirming the hypothesis, increased synovial levels of aggrecan, bFGF, BMP-7, and CD105 were found in patients over 18 years. This correlated with a higher stage of OA determined by radiographic changes or deteriorated function and may offer starting points for new diagnostics and interventional strategies. LEVEL OF EVIDENCE: II.
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