ArticleClinics (Sao Paulo, Brazil)2013
Effects of ovariectomy and resistance training on oxidative stress markers in the rat liver.
Article in Clinics (Sao Paulo, Brazil), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- The Effect of Resistance Training on Serum Levels of Lipid Profile and Liver Enzymes in Male Rat Undergoing Radiotherapy.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Bee venom-derived phospholipase AFrontiers in psychiatry · 2025Article
- Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis.International journal of molecular sciences · 2024Article
- Plasma metabolomics reveals the intervention mechanism of different types of exercise on chronic unpredictable mild stress-induced depression rat model.Metabolic brain disease · 2024Article
- Improved Activity of Herbal Medicines through Nanotechnology.Nanomaterials (Basel, Switzerland) · 2022Review
- The Role of Vitamin E in Thermal Burn Injuries, Infection, and Sepsis: A Review.Journal of burn care & research : official publication of the American Burn Association · 2022Review
- Strength Training Reduces Cardiac and Renal Oxidative Stress in Rats with Renovascular Hypertension.Arquivos brasileiros de cardiologia · 2021Article
- Protective Effects ofBioMed research international · 2021Article
- Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress.PloS one · 2020Article
- Seaweed Supplementation Enhances Maximal Muscular Strength and Attenuates Resistance Exercise-Induced Oxidative Stress in Rats.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Benefits of resistance training on body composition and glucose clearance are inhibited by long-term low carbohydrate diet in rats.PloS one · 2018Article
- Estrogen deficiency in ovariectomized rats: can resistance training re-establish angiogenesis in visceral adipose tissue?Clinics (Sao Paulo, Brazil) · 2016Article
- Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency.Experimental neurobiology · 2015Article
- Impact of ovariectomy, high fat diet, and lifestyle modifications on oxidative/antioxidative status in the rat liver.Croatian medical journal · 2014Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to assess the effects of resistance training on oxidative stress markers in the livers of ovariectomized rats.
methodAdult Sprague-Dawley rats were divided into the following four groups (n = 8 per group): sham-operated sedentary, ovariectomized sedentary, sham-operated resistance training, and ovariectomized resistance training. During the resistance training period, the animals climbed a 1.1-m vertical ladder with weights attached to their tails; the sessions were conducted 3 times per week, with 4-9 climbs and 8-12 dynamic movements per climb. The oxidative stress was assessed by measuring the levels of reduced glutathione and oxidized glutathione, the enzymatic activity of catalase and superoxide dismutase, lipid peroxidation, vitamin E concentrations, and the gene expression of glutathione peroxidase.
resultsThe results showed significant reductions in the reduced glutathione/oxidized glutathione ratio (4.11±0.65 nmol/g tec), vitamin E concentration (55.36±11.11 nmol/g), and gene expression of glutathione peroxidase (0.49±0.16 arbitrary units) in the livers of ovariectomized rats compared with the livers of unovariectomized animals (5.71±0.71 nmol/g tec, 100.14±10.99 nmol/g, and 1.09±0.54 arbitrary units, respectively). Moreover, resistance training for 10 weeks was not able to reduce the oxidative stress in the livers of ovariectomized rats and induced negative changes in the hepatic anti-oxidative/oxidative balance.
conclusionOur findings indicate that the resistance training program used in this study was not able to attenuate the hepatic oxidative damage caused by ovariectomy and increased the hepatic oxidative stress.
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