ArticleStem cell research2014
Hydrogel formulation determines cell fate of fetal and adult neural progenitor cells.
Article in Stem cell research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Minimally Invasive Syringe-Injectable Hydrogel with Angiogenic Factors for Ischemic Stroke Treatment.Advanced healthcare materials · 2025Article
- Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing.Cold Spring Harbor perspectives in biology · 2023Review
- Advances in currentFrontiers in bioengineering and biotechnology · 2023Review
- A review on 3D printing functional brain model.Biomicrofluidics · 2022Review
- Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation.Molecular brain · 2020Article
- Hydrogel systems and their role in neural tissue engineering.Journal of the Royal Society, Interface · 2020Review
- A roadmap for promoting endogenous in situ tissue restoration using inductive bioscaffolds after acute brain injury.Brain research bulletin · 2019Review
- Peptide-modified, hyaluronic acid-based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering.Journal of biomedical materials research. Part A · 2019Article
- Encapsulation of Biological Agents in Hydrogels for Therapeutic Applications.Gels (Basel, Switzerland) · 2018Review
- Ex vivo biomechanical characterization of syringe-needle ejections for intracerebral cell delivery.Scientific reports · 2018Article
- Engineering Hydrogel Microenvironments to Recapitulate the Stem Cell Niche.Annual review of biomedical engineering · 2018Review
- Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality.Polymers · 2018Review
- ECM hydrogel for the treatment of stroke: Characterization of the host cell infiltrate.Biomaterials · 2016Article
- Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue.Journal of visualized experiments : JoVE · 2015Article
- In vitro bioengineered model of cortical brain tissue.Nature protocols · 2015Article
- Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture.Advanced healthcare materials · 2015Article
- 3D in vitro modeling of the central nervous system.Progress in neurobiology · 2015Review
- Profile analysis of hepatic porcine and murine brain tissue slices obtained with a vibratome.PeerJ · 2015Article
- 3D brain tissue physiological model with co-cultured primary neurons and glial cells in hydrogels.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Hydrogels provide a unique tool for neural tissue engineering. These materials can be customized for certain functions, i.e. to provide cell/drug delivery or act as a physical scaffold. Unfortunately, hydrogel complexities can negatively impact their biocompatibility, resulting in unintended consequences. These adverse effects may be combated with a better understanding of hydrogel chemical, physical, and mechanical properties, and how these properties affect encapsulated neural cells. We defined the polymerization and degradation rates and compressive moduli of 25 hydrogels formulated from different concentrations of hyaluronic acid (HA) and poly(ethylene glycol) (PEG). Changes in compressive modulus were driven primarily by the HA concentration. The in vitro biocompatibility of fetal-derived (fNPC) and adult-derived (aNPC) neural progenitor cells was dependent on hydrogel formulation. Acute survival of fNPC benefited from hydrogel encapsulation. NPC differentiation was divergent: fNPC differentiated into mostly glial cells, compared with neuronal differentiation of aNPC. Differentiation was influenced in part by the hydrogel mechanical properties. This study indicates that there can be a wide range of HA and PEG hydrogels compatible with NPC. Additionally, this is the first study comparing hydrogel encapsulation of NPC derived from different aged sources, with data suggesting that fNPC and aNPC respond dissimilarly within the same hydrogel formulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.