Evidence map›Paper›PMID 24141091›Full record

ReviewMicrobes and infection2013

Breaking in and grabbing a meal: Anaplasma phagocytophilum cellular invasion, nutrient acquisition, and promising tools for their study.

Hilary K Truchan, David Seidman, Jason A Carlyon

Open access · greenAbstract readReview
In one paragraph

Review in Microbes and infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Machine Learning-Based Detection ofPathogens (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Innate immunity in rickettsial infections.Frontiers in cellular and infection microbiology · 2023
    Review
  5. Review
  6. Article
  7. Global Transcription Profiles ofFrontiers in veterinary science · 2020
    Article
  8. Article
  9. Alternative Splicing of Differentiated Myeloid Cell Transcripts after Infection byFrontiers in cellular and infection microbiology · 2018
    Article
  10. Frontiers in immunology · 2018
    Article
  11. Article
  12. Article
  13. Genome-WideFrontiers in cellular and infection microbiology · 2016
    Article
  14. Article
  15. Frontiers in cellular and infection microbiology · 2016
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hilary K TruchanDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0678, USA.
David Seidman
Jason A Carlyon
Virginia Commonwealth University · US

Funding

The roles of Anaplasma phagocytophilum surface proteins in infectionR01AI072683 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CARLYON, JASON A · 2007 to 2021
$5.8M
VCU Neuroscience Center Core GrantP30NS047463 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI POVLISHOCK, JOHN T · 2003 to 2013
$5.0M
The roles of Anaplasma phagocytophilum surface proteins in infectionR37AI072683 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI Jason A Carlyon · 2022 to 2026
$2.6M
The roles of Anaplasma phagocytophilum surface proteins in cellular invasionR56AI072683 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CARLYON, JASON A · 2012 to 2012
$368k
NIAID NIH HHS 2R56 AI067283NIAID NIH HHS R01 AI072683NIAID NIH HHS R37 AI072683NIAID NIH HHS R56 AI072683NINDS NIH HHS 5P30NS047463NINDS NIH HHS P30 NS047463
6 · The paper itself

Abstract

Anaplasma phagocytophilum invades neutrophils to cause the emerging infection, human granulocytic anaplasmosis. Here, we provide a focused review of the A. phagocytophilum invasin-host cell receptor interactions that promote bacterial entry and the degradative and membrane traffic pathways that the organism exploits to route nutrients to the organelle in which it resides. Because its obligatory intracellular nature hinders knock out-complementation approaches, we also discuss the current methods used to study A. phagocytophilum gene function and the potential benefit of applying novel tools that have advanced studies of other obligate intracellular bacterial pathogens.

Indexed as

Anaplasma phagocytophilumAnimalsBacterial AdhesionBacterial ProteinsEhrlichiosisHost-Pathogen InteractionsHumansIntracellular SpaceProtein BindingReceptors, Cell SurfaceVirulenceBacterial ProteinsReceptors, Cell SurfaceBacterial invasionEhrlichiaNutritional virulenceObligate intracellularRab GTPaseRickettsia

Identifiers

PMID24141091
PMCPMC3894830
OpenAlexW2033851131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.