ArticleBone2014
Positive effects of brown adipose tissue on femoral bone structure.
Article in Bone, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Understanding neurodevelopmental proteasomopathies as new rare disease entities: A review of current concepts, molecular biomarkers, and perspectives.Genes & diseases · 2024Review
- Brown fat-specific mitoribosomal function is crucial for preventing cold exposure-induced bone loss.Cellular and molecular life sciences : CMLS · 2024Article
- Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9.iScience · 2024Article
- The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis.Frontiers in endocrinology · 2023Review
- Exploring the relationship of brown adipose tissue to bone microarchitecture using 7T MRI and micro-CT.Histology and histopathology · 2022Article
- Bone density and genomic analysis unfold cold adaptation mechanisms of ancient inhabitants of Tierra del Fuego.Scientific reports · 2021Article
- Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.Journal of cellular physiology · 2021Article
- Brown Adipose Tissue Rescues Bone Loss Induced by Cold Exposure.Frontiers in endocrinology · 2021Article
- Brown adipose tissue and cancer progression.Skeletal radiology · 2020Article
- Article
- Association between brown adipose tissue and bone mineral density in humans.International journal of obesity (2005) · 2019Article
- Preliminary investigation of brown adipose tissue assessed by PET/CT and cancer activity.Skeletal radiology · 2019Article
- The Impact of Childhood Obesity on Skeletal Health and Development.Journal of obesity & metabolic syndrome · 2019Review
- Low temperature decreases bone mass in mice: Implications for humans.American journal of physical anthropology · 2018Article
- Sexual Dimorphism and the Origins of Human Spinal Health.Endocrine reviews · 2018Review
- Obesity is a concern for bone health with aging.Nutrition research (New York, N.Y.) · 2017Review
- Adipose tissue and muscle attenuation as novel biomarkers predicting mortality in patients with extremity sarcomas.European radiology · 2016Article
- Imaging of Brown Adipose Tissue: State of the Art.Radiology · 2016Review
- Review
- Brown adipose tissue and bone.International journal of obesity supplements · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeRecent studies suggest a link between brown adipose tissue (BAT) and bone. The purpose of our study was to investigate the effects of BAT on femoral bone structure. MATERIALS AND
methodsWe studied 105 patients (19 m, 86 f. mean age 45.5±16.1 years) who underwent F18-FDG positron emission tomography/computed tomography (PET/CT) for benign etiologies (n=20) or follow-up of successfully treated malignancies (n=85); mean time between PET/CT and last form of treatment was 14.8±18.0 months. BAT volume by PET/CT; femoral bone structure by CT (total femoral cross-sectional area (CSA), cortical CSA); and thigh muscle CSA and thigh subcutaneous fat CSA by CT was assessed.
resultsThere were positive correlations between BAT volume and total femoral CSA and cortical CSA, independent of age, BMI and history of malignancy (p<0.05). BAT volume correlated positively with thigh muscle CSA and thigh fat CSA (p<0.05). When total femoral CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables in a forward stepwise regression model, BAT volume was the only predictor of total femoral CSA. When femoral cortical CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables, BAT volume was the only predictor of femoral cortical CSA.
conclusionBAT volume is a positive predictor of femoral bone structure and correlates positively with thigh muscle and subcutaneous fat, possibly mediated by muscle. These results provide further evidence of a positive effect of BAT on bone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.