ArticleJournal of controlled release : official journal of the Controlled Release Society2013
Development of a poly(ether urethane) system for the controlled release of two novel anti-biofilm agents based on gallium or zinc and its efficacy to prevent bacterial biofilm formation.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Layer-By-Layer Functionalized Gauze With Designed α-Sheet Peptides Inhibits E. coli and S. aureus Biofilm Formation.Journal of biomedical materials research. Part A · 2025Article
- Gallium-Based Liquid Metal Materials for Antimicrobial Applications.Bioengineering (Basel, Switzerland) · 2022Review
- Polymeric Nanosystems Applied for Metal-Based Drugs and Photosensitizers Delivery: The State of the Art and Recent Advancements.Pharmaceutics · 2022Review
- Metal Complexes-A Promising Approach to Target Biofilm Associated Infections.Molecules (Basel, Switzerland) · 2022Review
- Gallium ions incorporated silk fibroin hydrogel with antibacterial efficacy for promoting healing ofFrontiers in chemistry · 2022Article
- Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Development of Active Barrier Multilayer Films Based on Electrospun Antimicrobial Hot-Tack Food Waste Derived Poly(3-hydroxybutyrate-Nanomaterials (Basel, Switzerland) · 2020Article
- Surface treatment strategies to combat implant-related infection from the beginning.Journal of orthopaedic translation · 2019Review
- Nanoscience-Based Strategies to Engineer Antimicrobial Surfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Review
- Development of a root canal treatment model in the rat.Scientific reports · 2017Article
- A Topical Hydrogel with Deferiprone and Gallium-Protoporphyrin Targets Bacterial Iron Metabolism and Has Antibiofilm Activity.Antimicrobial agents and chemotherapy · 2017Article
- Acinetobacter baumannii Biofilm Formation in Human Serum and Disruption by Gallium.Antimicrobial agents and chemotherapy · 2017Article
- Metal-containing and related polymers for biomedical applications.Chemical Society reviews · 2016Article
- Activity of Gallium Meso- and Protoporphyrin IX against Biofilms of Multidrug-Resistant Acinetobacter baumannii Isolates.Pharmaceuticals (Basel, Switzerland) · 2016Article
- Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices.BioMed research international · 2016Review
- An In Vitro Comparison of PMMA and Calcium Sulfate as Carriers for the Local Delivery of Gallium(III) Nitrate to Staphylococcal Infected Surgical Sites.BioMed research international · 2016Article
- Gallium-Loaded Dissolvable Microfilm Constructs that Provide Sustained Release of Ga(3+) for Management of Biofilms.Advanced healthcare materials · 2015Article
- Scaffold-based anti-infection strategies in bone repair.Annals of biomedical engineering · 2015Review
- Predicting Ecological Roles in the Rhizosphere Using Metabolome and Transportome Modeling.PloS one · 2015Article
- A Single B-repeat of Staphylococcus epidermidis accumulation-associated protein induces protective immune responses in an experimental biomaterial-associated infection mouse model.Clinical and vaccine immunology : CVI · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Traditional antibiotic therapy to control medical device-based infections typically fails to clear biofilm infections and may even promote the evolution of antibiotic resistant species. We report here the development of two novel antibiofilm agents; gallium (Ga) or zinc (Zn) complexed with protoporphyrin IX (PP) or mesoprotoporphyrin IX (MP) that are both highly effective in negating suspended bacterial growth and biofilm formation. These chelated gallium or zinc complexes act as iron siderophore analogs, supplanting the natural iron uptake of most bacteria. Poly (ether urethane) (PEU; Biospan®) polymer films were fabricated for the controlled sustained release of the Ga- or Zn-complexes, using an incorporated pore-forming agent, poly(ethylene glycol) (PEG). An optimum formulation containing 8% PEG (MW=1450) in the PEU polymer effectively sustained drug release for at least 3months. All drug-loaded PEU films exhibited in vitro ≥ 90% reduction of Gram-positive (Staphylococcus epidermidis) and Gram-negative (Pseudomonas aeruginosa) bacteria in both suspended and biofilm culture versus the negative control PEU films releasing nothing. Cytotoxicity and endotoxin evaluation demonstrated no adverse responses to the Ga- or Zn-complex releasing PEU films. Finally, in vivo studies further substantiate the anti-biofilm efficacy of the PEU films releasing Ga- or Zn- complexes.
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