ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Cytomegalovirus-seropositive children show inhibition of in vitro EBV infection that is associated with CD8+CD57+ T cell enrichment and IFN-γ.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Epstein-Barr virus-driven immunosuppression in nasopharyngeal carcinoma: a comprehensive review of viral mechanisms, spatial tumor ecosystems, and precision therapeutics.Frontiers in immunology · 2026Pooled it
- Multiple Childhood Respiratory Viral Infections Are Associated with Allergy in Young Adults.International archives of allergy and immunology · 2026Article
- Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation.International journal of molecular sciences · 2024Article
- Isolation of Epstein-Barr virus-deoxyribonucleic acid in the lower respiratory tract for distinguishing critically ill patients from those with influenza-associated pneumonia: A pilot study.The clinical respiratory journal · 2023Article
- Four-Parameter FluoroSpot Assay Reveals That the Varicella Zoster Virus Elicits a Robust Memory T Cell IL-10 Response throughout Childhood.Journal of virology · 2022Article
- Review
- Characterization of the γδ T-cell compartment during infancy reveals clear differences between the early neonatal period and 2 years of age.Immunology and cell biology · 2020Article
- Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Programmed death 1 is highly expressed on CD8Immunology · 2017Article
- Asymptomatic Primary Infection with Epstein-Barr Virus: Observations on Young Adult Cases.Journal of virology · 2017Observational
- Known unknowns: how might the persistent herpesvirome shape immunity and aging?Current opinion in immunology · 2017Review
- A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness.GeroScience · 2017Review
- Epstein-Barr Virus, but Not Cytomegalovirus, Latency Accelerates the Decay of Childhood Measles and Rubella Vaccine Responses-A 10-Year Follow-up of a Swedish Birth Cohort.Frontiers in immunology · 2017Article
- High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults.PloS one · 2017Article
- Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets.Frontiers in immunology · 2016Review
- Associations between EBV and CMV Seropositivity, Early Exposures, and Gut Microbiota in a Prospective Birth Cohort: A 10-Year Follow-up.Frontiers in pediatrics · 2016Article
- Epstein-Barr virus coinfection in children boosts cytomegalovirus-induced differentiation of natural killer cells.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EBV, a human herpesvirus, is commonly acquired during childhood and persists latently in B cells. EBV seropositivity has been connected to immunomodulatory effects such as altered T and NK cell functional responses as well as protection against early IgE sensitization; however, owing to the asymptomatic presentation during childhood little is known regarding the infection process in children of different ages. In this study, we used mononuclear cells from cord blood and from 2- and 5-y-old EBV-naive children for in vitro EBV infection. We show that the degree of EBV-induced B cell activation and expansion differs between age groups and in particular in relationship to IFN-γ production capacity. EBV infection induced redistribution between B cell subsets with enrichment of IgD(+)CD27(+) cells (commonly referred to as non-switched memory) in infected cord blood cell cultures, and of IgD(-)CD27(+) cells (switched memory) in cell cultures from older children. We also related results to serostatus to CMV, a persistent herpesvirus that can affect differentiation status of T and NK cells. As compared with CMV(-) children, the EBV-induced enrichment of IgD(-)CD27(+) B cells was significantly reduced in infected cell cultures from CMV(+) children. This effect was associated with high levels of IFN-γ and frequencies of highly mature CD8(+)CD57(+) T cells in CMV(+) children. Our results demonstrate that both a child's age and serostatus to CMV will have an impact on EBV-induced B cell activation and expansion, and they point to the ability of viruses with immunomodulatory functions, such as CMV, to affect immune responses within the host system.
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