ArticleHearing research2013
Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus.
Article in Hearing research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Age-related ultrastructural differences in the dorsal cortex of the inferior colliculus in the fischer brown Norway rat.Neurobiology of aging · 2026Article
- Distinct Neuron Types Contribute to Hybrid Auditory Spatial Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Subcortical coding of predictable and unsupervised sound-context associations.Current research in neurobiology · 2023Article
- Inhibitory NPY Neurons Provide a Large and Heterotopic Commissural Projection in the Inferior Colliculus.Frontiers in neural circuits · 2022Article
- A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice.eLife · 2019Article
- Bilateral projections to the thalamus from individual neurons in the inferior colliculus.The Journal of comparative neurology · 2019Article
- GABAergic and non-GABAergic projections to the superior colliculus from the auditory brainstem.Brain structure & function · 2018Article
- Neuronal Organization in the Inferior Colliculus Revisited with Cell-Type-Dependent Monosynaptic Tracing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Commissural Gain Control Enhances the Midbrain Representation of Sound Location.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Extracellular Molecular Markers and Soma Size of Inhibitory Neurons: Evidence for Four Subtypes of GABAergic Cells in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Corticofugal modulation of peripheral auditory responses.Frontiers in systems neuroscience · 2015Review
- Article
- The auditory corticocollicular system: molecular and circuit-level considerations.Hearing research · 2014Review
- Perineuronal nets and GABAergic cells in the inferior colliculus of guinea pigs.Frontiers in neuroanatomy · 2014Article
- Ultrastructural characterization of GABAergic and excitatory synapses in the inferior colliculus.Frontiers in neuroanatomy · 2014Article
- Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus.Frontiers in neuroanatomy · 2014Article
- Distribution of GABAergic cells in the inferior colliculus that project to the thalamus.Frontiers in neuroanatomy · 2014Article
- Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus.Frontiers in systems neuroscience · 2014Article
- Article
- Electron microscopy demonstrating noise exposure alters synaptic vesicle size in the inferior colliculus of cat.Noise & healthArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Projections from auditory cortex (AC) affect how cells in both inferior colliculi (IC) respond to acoustic stimuli. The large projection from the AC to the ipsilateral IC is usually credited with the effects in the ipsilateral IC. The circuitry underlying effects in the contralateral IC is less clear. The direct projection from the AC to the contralateral IC is relatively small. An unexplored possibility is that the large ipsilateral cortical projection contacts the substantial number of cells in the ipsilateral IC that project through the commissure to the contralateral IC. Apparent contacts between cortical boutons and commissural cells were identified in the left IC after injection of different fluorescent tracers into the left AC and the right IC. Commissural cells were labeled throughout the left IC, and many (23-34%) appeared to be contacted by cortical axons. In the central nucleus, both disc-shaped and stellate cells were contacted. Antibodies to glutamic acid decarboxylase (GAD) were used to identify GABAergic commissural cells. The majority (>86%) of labeled commissural cells were GAD-immunonegative. Despite low numbers of GAD-immunopositive commissural cells, some of these cells were contacted by cortical boutons. Nonetheless, most cortically contacted commissural cells were GAD-immunonegative (i.e., presumably glutamatergic). We conclude that auditory cortical axons contact primarily excitatory commissural cells in the ipsilateral IC that project to the contralateral IC. These corticocollicular contacts occur in each subdivision of the ipsilateral IC, suggesting involvement of commissural cells throughout the IC. This pathway - from AC to commissural cells in the ipsilateral IC - is a prime candidate for the excitatory effects of activation of the auditory cortex on responses in the contralateral IC. Overall this suggests that the auditory corticofugal pathway is integrated with midbrain commissural connections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.