ArticleFEBS letters2013
Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4α.
Article in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Fatty acid binding protein 1 (FABP1) depletion promotes an oxidative metabolic shift in Caco-2 colorectal cancer cells.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025Article
- Tissue-Specific Ablation of Liver Fatty Acid-Binding Protein Induces a Metabolically Healthy Obese Phenotype in Female Mice.Nutrients · 2025Article
- Tissue-Specific Ablation of Liver Fatty Acid-Binding Protein Induces a Metabolically Healthy Obese Phenotype in Female Mice.bioRxiv : the preprint server for biology · 2025Article
- Article
- Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Dietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes.Nature reviews. Cardiology · 2019Review
- FABP1 knockdown in human enterocytes impairs proliferation and alters lipid metabolism.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Article
- Crosstalk of HNF4Acta pharmaceutica Sinica. B · 2016Review
- Review
- Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei.Journal of lipid research · 2016Article
- 3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice.Frontiers in physiology · 2016Article
- Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine.Prostaglandins, leukotrienes, and essential fatty acids · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Hepatocyte nuclear factor 4α (HNF4α) regulates liver type fatty acid binding protein (L-FABP) gene expression. Conversely as shown herein, L-FABP structurally and functionally also interacts with HNF4α. Fluorescence resonance energy transfer (FRET) between Cy3-HNF4α (donor) and Cy5-L-FABP (acceptor) as well as FRET microscopy detected L-FABP in close proximity (~80 Å) to HNF4α, binding with high affinity Kd ~250-300 nM. Circular dichroism (CD) determined that the HNF4α/L-FABP interaction altered protein secondary structure. Finally, L-FABP potentiated transactivation of HNF4α in COS7 cells. Taken together, these data suggest that L-FABP provides a signaling path to HNF4α activation in the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.