Evidence map›Paper›PMID 24140311›Full record

ArticleReproductive biomedicine online2014

Fertility preservation in patients with haematological disorders: a retrospective cohort study.

Suneeta Senapati, Christopher B Morse, Mary D Sammel, Jayeon Kim, Jennifer E Mersereau, Brenda Efymow, Clarisa R Gracia

Open access · bronzeAbstract read
In one paragraph

Article in Reproductive biomedicine online, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Random-start controlled ovarian stimulation for emergency fertility preservation in a patient with myelodysplastic syndrome: a case report.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016
    Article
  5. Outcomes of ovarian stimulation after treatment with chemotherapy.Journal of assisted reproduction and genetics · 2015
    Article
  6. Early referral makes the decision-making about fertility preservation easier: a pilot survey study of young female cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Suneeta SenapatiDepartment of Obstetrics and Gynecology, University of Pennsylvania, United States. Electronic address: Suneeta.Senapati@uphs.upenn.edu.
Christopher B MorseDepartment of Obstetrics and Gynecology, University of Pennsylvania, United States.
Mary D SammelDepartment of Obstetrics and Gynecology, University of Pennsylvania, United States.
Jayeon KimDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, United States.
Jennifer E MersereauDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, United States.
Brenda EfymowDepartment of Obstetrics and Gynecology, University of Pennsylvania, United States.
Clarisa R GraciaDepartment of Obstetrics and Gynecology, University of Pennsylvania, United States.
University of Pennsylvania · USUniversity of North Carolina at Chapel Hill · US

Funding

Environmental Science Project 3 - Social Determinants of Risk and Attitudes AboutP42ES023720 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI PEPINO, RICHARD · 2014 to 2018
$11.3M
REPRODUCTIVE EPIDEMIOLOGY TRAINING GRANTT32HD007440 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BARNHART, KURT T · 1996 to 2020
$7.5M
Measures of Fertility in Young Cancer PatientsKL1CA133839 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GRACIA, CLARISA R. · 2007 to 2011
$786k
Training the Global Ready ScholarRL9CA133838 · NCI · UNIVERSITY OF PENNSYLVANIA · PI COUTIFARIS, CHRISTOS · 2007 to 2011
$472k
Training the Global Ready ScholarTL1CA133837 · NCI · UNIVERSITY OF PENNSYLVANIA · PI COUTIFARIS, CHRISTOS · 2007 to 2009
$416k
NCI NIH HHS KL1 CA133839NCI NIH HHS RL9 CA133838NCI NIH HHS TL1 CA133837NICHD NIH HHS T32 HD007440NIEHS NIH HHS P42 ES023720
6 · The paper itself

Abstract

This study investigated the factors associated with utilization of fertility preservation and the differences in treatments and outcomes by prior chemotherapy exposure in patients with haematological diseases. This study included all 67 women with haematological diseases seen for fertility preservation consultation at two university hospitals between 2006 and 2011. Of the total, 49% had lymphoma, 33% had leukaemia, 7% had myelodysplastic syndrome and 4% had aplastic anaemia; 46% had prior chemotherapy; and 33% were planning for bone marrow transplantation, 33% pursued ovarian stimulation and 7% used ovarian tissue banking; and 48% of patients did not pursue fertility preservation treatment. All five cycle cancellations were in the post-chemotherapy group: three patients with leukaemia and two with lymphoma. Patients with prior chemotherapy had lower baseline antral follicle count (10 versus 22) and received more gonadotrophins to achieve similar peak oestradiol concentrations, with no difference in oocyte yield (10.5 versus 10) after adjustment for age. Embryo yield was similar between those who had prior chemotherapy and those who had not. Half of the patients with haematological diseases who present for fertility preservation have been exposed to chemotherapy. While ovarian reserve is likely impaired in this group, oocyte yield may be acceptable.

Indexed as

Reproductive Techniques, AssistedCohort StudiesDrug-Related Side Effects and Adverse ReactionsEstradiolFemaleFertility PreservationGonadotropinsHematologic DiseasesHumansOvarian FollicleRegression AnalysisRetrospective StudiesEstradiolGonadotropinscancerfertility preservationhaematological diseaseIVFovarian reserve

Identifiers

PMID24140311
PMCPMC4151874
OpenAlexW1996407549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.