Evidence map›Paper›PMID 24140295›Full record

ReviewTrends in parasitology2013

Could culicine mosquitoes transmit human malaria?

Alvaro Molina-Cruz, Tovi Lehmann, Julia Knöckel

Open access · greenAbstract readReview
In one paragraph

Review in Trends in parasitology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Phylogenomics redefines the evolutionary history of mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Anopheles jamesii Supports Plasmodium vivax Sporogony under Laboratory Conditions.The American journal of tropical medicine and hygiene · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alvaro Molina-CruzLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Tovi Lehmann
Julia Knöckel
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

Ecology of Disease VectorsZIAAI001196 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LEHMANN, TOVI · 2014 to 2025
$8.9M
Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Human malaria is known to be transmitted strictly by anopheline mosquitoes. Culicine mosquitoes such as Aedes spp. and Culex spp. are important vectors of other human pathogens including viruses and filarial worms, but have never been observed to transmit mammalian malarias. Culicines do transmit avian malarias and, interestingly, allow partial development of mammalian-infectious Plasmodium parasites, implying that physiological barriers in the mosquitoes prevent parasite transmission. Although the mechanism(s) are not known, the mosquito immune system is probably involved in eliminating Plasmodium. However, Plasmodium has shown substantial capacity to adapt to new vectors, and current ecological changes caused by humans could promote adaptation of human-infectious Plasmodium parasites to culicines. Such an event could have widespread epidemiological implications and therefore merits attention.

Indexed as

Disease VectorsAnimalsAnophelesCulexHumansMalariaPlasmodiumAnophelesCulexmalariamosquitotransmission

Identifiers

PMID24140295
PMCPMC10987011
OpenAlexW2056039804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.