Evidence map›Paper›PMID 24140081›Full record

ReviewPharmacology & therapeutics2014

Small and large animal models in cardiac contraction research: advantages and disadvantages.

Nima Milani-Nejad, Paul M L Janssen

Abstract readComparative StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacology & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

300 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Preclinical Large AnimalCurrent cardiology reviews · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Human cardiovascular organoids: Biomedical applications and ethical challenges.American heart journal plus : cardiology research and practice · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Large animal models of right heart failure due to pulmonary hypertension: a bridge to translational success.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. PET imaging of cardiac sympathetic nervous system dysfunction using meta-[European journal of nuclear medicine and molecular imaging · 2026
    Article
  19. Article
  20. Review

240 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nima Milani-NejadDepartment of Physiology and Cell Biology and D. Davis Heart Lung Institute, College of Medicine, The Ohio State University, OH, USA.
Paul M L JanssenDepartment of Physiology and Cell Biology and D. Davis Heart Lung Institute, College of Medicine, The Ohio State University, OH, USA. Electronic address: janssen.10@osu.edu.

Funding

Frequency-dependent modulation of cardiac myofilament function in health/diseaseR01HL113084 · NHLBI · OHIO STATE UNIVERSITY · PI JANSSEN, PAULUS ML · 2012 to 2023
$4.6M
Electrical and mechanical behavior of live human myocardium in health and diseaseRC1HL099538 · NHLBI · OHIO STATE UNIVERSITY · PI JANSSEN, PAULUS ML · 2009 to 2010
$1.0M
NHLBI NIH HHS R01 HL113084NHLBI NIH HHS R01HL113084NHLBI NIH HHS RC1 HL099538
6 · The paper itself

Abstract

The mammalian heart is responsible for not only pumping blood throughout the body but also adjusting this pumping activity quickly depending upon sudden changes in the metabolic demands of the body. For the most part, the human heart is capable of performing its duties without complications; however, throughout many decades of use, at some point this system encounters problems. Research into the heart's activities during healthy states and during adverse impacts that occur in disease states is necessary in order to strategize novel treatment options to ultimately prolong and improve patients' lives. Animal models are an important aspect of cardiac research where a variety of cardiac processes and therapeutic targets can be studied. However, there are differences between the heart of a human being and an animal and depending on the specific animal, these differences can become more pronounced and in certain cases limiting. There is no ideal animal model available for cardiac research, the use of each animal model is accompanied with its own set of advantages and disadvantages. In this review, we will discuss these advantages and disadvantages of commonly used laboratory animals including mouse, rat, rabbit, canine, swine, and sheep. Since the goal of cardiac research is to enhance our understanding of human health and disease and help improve clinical outcomes, we will also discuss the role of human cardiac tissue in cardiac research. This review will focus on the cardiac ventricular contractile and relaxation kinetics of humans and animal models in order to illustrate these differences.

Indexed as

Models, AnimalAnimalsDisease Models, AnimalHeart DiseasesHeart VentriclesHumansMyocardial ContractionSpecies SpecificityVentricular FunctionAAVaction potential durationadeno-associated virusAPDCardiac contractilityCardiac kineticsdF/dt(max)(dF/dt(max))/FdF/dt(min)(dF/dt(min))/FHeart failureHeart rateleft ventricular isovolumic relaxation time constantleft ventricular maximal rate of pressure declineleft ventricular maximal rate of pressure riseleft ventricular systolic pressureLV dP/dt(max)LV dP/dt(min)LVSPLV τMaximal velocity of contraction divided by developed force in cardiac trabeculaeMaximal velocity of contraction in cardiac trabeculaeMaximal velocity of relaxation divided by developed force in cardiac trabeculaeMaximal velocity of relaxation in cardiac trabeculaeMHCmyosin heavy chainNCXRelaxation time 50%: Time from peak force to 50% relaxation in cardiac trabeculaeRT(50)sarcoplasmic-reticulum calcium ATPaseSERCAsodium calcium exchangerSpeciestime to peak: time from stimulation to peak force in cardiac trabeculaeTTP

Identifiers

PMID24140081
PMCPMC3947198

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.