Evidence map›Paper›PMID 24140080›Full record

ArticlePlacenta2013

Evidence of sexual dimorphism in the placental function with severe preeclampsia.

S Muralimanoharan, A Maloyan, L Myatt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Observational
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  15. Review
  16. The Placenta's Role in Sexually Dimorphic Fetal Growth Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

S MuralimanoharanCenter for Pregnancy and Newborn Research, Dept of OB/GYN, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.
A Maloyan
L Myatt
The University of Texas Health Science Center at San Antonio · US

Funding

Protein Nitration in the PlacentaR01HL075297 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MYATT, LESLIE · 2004 to 2012
$3.1M
NHLBI NIH HHS R01 HL075297
6 · The paper itself

Abstract

Preeclampsia (PE) affects 5-8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammatory and apoptotic responses in preeclamptic pregnancies. Placentas were collected from normotensive and preeclamptic pregnancies with either male or female fetuses (MPE and FPE respectively) after c-section at term with no labor. Expression patterns of markers of inflammation measured by ELISA, as well as hypoxia, apoptosis and angiogenesis markers measured by Western blotting were determined in the placenta. Consistent with previous studies, an increase in inflammation, hypoxia, and apoptotic cell death was observed in PE compared to normotensive pregnancies. Levels of TNFα, IL-6 and IL-8, and HIF-1α were significantly greater, whereas the angiogenic marker VEGF was significantly reduced in MPE vs. FPE. Sexual dimorphism was also observed in the activation of cell death: the number of TUNEL-positive cells, and the expression pro-apoptotic markers PUMA and Bax being higher in MPE vs. FPE. We also found an increase in the levels of protein and DNA-binding activity of NFκB p65 in MPE vs. FPE. In summary, we show here that in preeclamptic pregnancies the placentas of males were associated with significantly higher expression of inflammatory, hypoxia and apoptotic molecules but reduced expression of a pro-angiogenic marker compared to placentas of female fetuses. We propose that the transcription factor NFκB p65 might, at least partially, be involved in sexual dimorphism during PE.

Indexed as

Fetal DevelopmentAdultAngiogenic ProteinsApoptosisBiomarkersCell HypoxiaCell NucleusCesarean SectionCytokinesFemaleHumansInfant, NewbornMalePlacentaPre-EclampsiaPregnancyAngiogenic ProteinsBiomarkersCytokinesRELA protein, humanTranscription Factor RelAApoptosisBMIbody mass indexHIF-1αhypoxia inducible factor-1alphaIL-6IL-8Inflammationinterleukin 6interleukin-8NFκBNFκB p65nuclear factor kappa Bp53 upregulated modulator of apoptosisPEpreeclampsiaPreeclampsiaPUMASexual dimorphismTNFαtumor necrosis factor alphavascular endothelial growth factorVEGF

Identifiers

PMID24140080
PMCPMC3868439
OpenAlexW2083230653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.