ArticleCurrent biology : CB2013
Meiotic adaptation to genome duplication in Arabidopsis arenosa.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.
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143 citing papers in PubMed.
- Whole-genome duplication promotes phenotypic and genetic adaptation to elevation.The New phytologist · 2026Article
- Article
- Cross-ploidy hybridisation in Alpine woodrushes is associated with ecological additivity and scale-dependent niche divergence.The New phytologist · 2026Article
- Tuning Meiotic Checkpoints: Evolutionary Costs and Mechanistic Trade-Offs.Annual review of genetics · 2026Review
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Somatic genome-doubling is the most parsimonious route to allopolyploidy.The New phytologist · 2026Review
- Recombination and the role of pseudo-overdominance in polyploid evolution.G3 (Bethesda, Md.) · 2026Article
- Aneuploidy confers environmentally robust higher evolvability than euploidy in a synthetic allotetraploid wheat.Science advances · 2026Article
- Polyploidy and plant resilience to environmental stresses: Molecular mechanisms and future applications.Plant communications · 2026Review
- Hybridization and Polyploidy Shaped the Evolutionary History of a Complex of Cryptic Species in European Woodrushes (Luzula sect. Luzula).Systematic biology · 2026Article
- Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica.The New phytologist · 2026Article
- Human selection maintains karyotype integrity of highly unstable genomic cultivated autotetraploid potato (Science advances · 2025Article
- SCEP3 initiates synapsis and implements crossover interference in Arabidopsis.Nature plants · 2025Article
- Whole-Genome Duplication Reshapes Adaptation: Autotetraploid Arabidopsis arenosa Leverages its High Genetic Variation to Compensate for Selection Constraints.Molecular biology and evolution · 2025Article
- Whole-genome duplication increases genetic diversity and load in outcrossingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multiple Autopolyploid Arabidopsis lyrata Populations Stabilized by Long-Range Adaptive Introgression Across Eurasia.Molecular biology and evolution · 2025Article
- The subordinate role of pseudogenization to recombinative deletion following polyploidization in angiosperms.Nature communications · 2025Article
- Comparative transcriptome analysis reveals key genes associated with meiotic stability and high seed setting rate in tetraploid rice.BMC plant biology · 2025Article
- Improved synapsis dynamics accompany meiotic stability inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Regulation of transcriptional homeostasis by DNA methylation upon genome duplication in pak choi.Molecular horticulture · 2025Article
83 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Whole genome duplication (WGD) is a major factor in the evolution of multicellular eukaryotes, yet by doubling the number of homologs, WGD severely challenges reliable chromosome segregation, a process conserved across kingdoms. Despite this, numerous genome-duplicated (polyploid) species persist in nature, indicating early problems can be overcome. Little is known about which genes are involved--only one has been molecularly characterized. To gain new insights into the molecular basis of adaptation to polyploidy, we investigated genome-wide patterns of differentiation between natural diploids and tetraploids of Arabidopsis arenosa, an outcrossing relative of A. thaliana. We first show that diploids are not preadapted to polyploid meiosis. We then use a genome scanning approach to show that although polymorphism is extensively shared across ploidy levels, there is strong ploidy-specific differentiation in 39 regions spanning 44 genes. These are discrete, mostly single-gene peaks of sharply elevated differentiation. Among these peaks are eight meiosis genes whose encoded proteins coordinate a specific subset of early meiotic functions, suggesting these genes comprise a polygenic solution to WGD-associated chromosome segregation challenges. Our findings indicate that even conserved meiotic processes can be capable of nimble evolutionary shifts when required.
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